Issues

The cover image was adapted from Figure 1 in the article, “miRNAs and Long-Term Breast Cancer Survival: Evidence from the WHEL Study,” by Natarajan and colleagues. Using the Women's Healthy Eating and Living (WHEL) breast cancer cohort with >15-years of follow-up and archived tumor specimens, the authors assayed PAM50 mRNAs and 25 miRNAs using the Nanostring nCounter platform. Two miRNAs, 210 and 29c, were associated with breast cancer outcomes in the WHEL and TCGA studies, and further improved risk stratification within PAM50 risk groups. The authors identified three additional miRNAs, 187-3p, 143-3p, and 205-5p via penalized regression. The findings suggest that miRNAs might be prognostic for long-term breast cancer survival and might improve risk stratification. For more information, see the article beginning on page 1525.