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ABOUT THE COVER
The cover image was adapted from Figure 1 in the article, "Transcriptomic Profiling Identifies a DNA Repair-Related Signature as a Novel Prognostic Marker in Lower Grade Gliomas," by Zeng and Liu, and colleagues. The authors identified a high-efficiency DNA damage repair-related risk signature as a predictor for prognosis in lower grade glioma. In Figure 1, the authors applied the LASSO Cox regression algorithm to select the most useful predictive features and identified four genes (CRY2, HDAC1, DCLRE1B, and KPNA2) with nonzero regression coefficients. The study concluded that the DNA damage repair-related signature was an independent and powerful prognostic biomarker in lower grade glioma. The signature may potentially improve risk stratification of patients and provide a more accurate assessment of personalized treatment in the clinic. For more information, see the article beginning on page 2079.