Issues

ABOUT THE COVER
The cover image was adapted from Figure 1 in the article, “Evidence for Etiologic Subtypes of Breast Cancer in the Carolina Breast Cancer Study,” by Benefield and colleagues. The authors evaluated clinical biomarkers and tumor suppressor p53 with risk factor data from cases and controls in the Carolina Breast Cancer Study, a population-based study of incident breast cancers. Figure 1 shows case–control odds ratios for ER/p53 and immunohistochemical intrinsic subtypes with P heterogeneity values. The study concluded that clinical marker–based intrinsic subtypes have established value, yet other schema may also yield important etiologic insights. For more information, see the article beginning on page 1784.