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1 October 2019
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Cover Image
Cover Image
The cover image was adapted from Figure 2 in the article, "Alterations to the Esophageal Microbiome Associated with Progression from Barrett's Esophagus to Esophageal Adenocarcinoma," by Snider and colleagues. The incidence of esophageal adenocarcinoma (EAC) has risen dramatically over the past half century, and the underlying reasons are incompletely understood. The goal of this case–control study was to describe alterations in the esophageal microbiome that occur with progression from Barrett's esophagus (BE) to EAC. Demographic, clinical, and dietary intake data were collected, and esophageal brushings were collected during the endoscopy. 16S rRNA gene sequencing was performed to characterize the microbiome. Shifts in the BE-associated microbiome were observed in patients with high-grade dysplasia and EAC, with increases in certain potentially pathogenic bacteria. Further studies are indicated to identify specific bacteria that may promote the development of EAC, and also whether therapies targeting the microbiome can be developed to modify the risk of EAC. For more information, see the full article beginning on page 1687.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1055-9965
EISSN 1538-7755
Highlights
Commentary
Cancer Progress and Priorities
Reviews
Research Articles
Positive STAT5 Protein and Locus Amplification Status Predicts Recurrence after Radical Prostatectomy to Assist Clinical Precision Management of Prostate Cancer
Bassem R. Haddad; Andrew Erickson; Vindhya Udhane; Peter S. LaViolette; Janice D. Rone; Markku A. Kallajoki; William A. See; Antti Rannikko; Tuomas Mirtti; Marja T. Nevalainen
Pretreatment Dietary Patterns Are Associated with the Presence of Nutrition Impact Symptoms 1 Year after Diagnosis in Patients with Head and Neck Cancer
Sylvia L. Crowder; Kalika P. Sarma; Alison M. Mondul; Yi Tang Chen; Zonggui Li; M. Yanina Pepino; Katie R. Zarins; Gregory T. Wolf; Laura S. Rozek; Anna E. Arthur
Evaluation of Rare and Common Variants from Suspected Familial or Sporadic Nasopharyngeal Carcinoma (NPC) Susceptibility Genes in Sporadic NPC
Zhiwei Liu; Alisa M. Goldstein; Wan-Lun Hsu; Kelly J. Yu; Yin-Chu Chien; Jenq-Yuh Ko; James Jer-Min Jian; Yung-An Tsou; Yi-Shing Leu; Li-Jen Liao; Yen-Liang Chang; Cheng-Ping Wang; Jia-Shing Wu; Chun-Hung Hua; Jehn-Chuan Lee; Tsung-Lin Yang; Chuhsing Kate Hsiao; Ming-Shiang Wu; Ming-Hsui Tsai; Kuei-Kang Huang; Kai Yu; Kristie Jones; Bin Zhu; Meredith Yeager; Guoqin Yu; Pei-Jen Lou; Chien-Jen Chen; Allan Hildesheim; for the GEV-NPC group
Author Choice
Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma
Majda Haznadar; Christopher M. Diehl; Amelia L. Parker; Kristopher W. Krausz; Elise D. Bowman; Siritida Rabibhadana; Marshonna Forgues; Vajarabhongsa Bhudhisawasdi; Frank J. Gonzalez; Chulabhorn Mahidol; Anuradha Budhu; Xin W. Wang; Mathuros Ruchirawat; Curtis C. Harris
Reproductive and Lifestyle Factors and Circulating sRANKL and OPG Concentrations in Women: Results from the EPIC Cohort
Danja Sarink; Jiaxi Yang; Theron Johnson; Jenny Chang-Claude; Kim Overvad; Anja Olsen; Anne Tjønneland; Agnès Fournier; Francesca Romana Mancini; Marina Kvaskoff; Heiner Boeing; Antonia Trichopoulou; Anna Karakatsani; Elissavet Valanou; Claudia Agnoli; Carlotta Sacerdote; Giovanna Masala; Amalia Mattiello; Rosario Tumino; Carla H. Van Gils; Guri Skeie; Inger Torhild Gram; Elisabete Weiderpass; Leila Lujan-Barroso; Dafina Petrova; Carmen Santiuste; J. Ramón Quirós; Aurelio Barricarte; Pilar Amiano; Ruth C. Travis; Marc Gunter; Laure Dossus; Sofia Christakoudi; Rudolf Kaaks; Renée Turzanski Fortner
Null Results in Brief
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