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Decades of investment into genomic science has led to a revolution in our understanding of the architecture of the human genome, genomic variation, and the biological consequences of the genome on human health and disease. Thanks to the technical and methodological advancements that enabled Genome-Wide Association Studies (GWAS), our understanding of the underlying genetics of most common diseases and traits has been fundamentally changed. In this special CEBP Focus issue, some of the leading figures in GWAS research in the past decades summarize what we have learned from this line of research and where the field can contribute biological and clinical insights into cancer.

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Timothy R. Rebbeck; Thomas A. Sellers
Doi: 10.1158/1055-9965.EPI-16-0914
Ben Kinnersley; Richard S. Houlston; Melissa L. Bondy
Doi: 10.1158/1055-9965.EPI-17-1080
Sungshim L. Park; Iona Cheng; Christopher A. Haiman
Doi: 10.1158/1055-9965.EPI-17-0169
Jenna Lilyquist; Kathryn J. Ruddy; Celine M. Vachon; Fergus J. Couch
Doi: 10.1158/1055-9965.EPI-17-1144
Siddhartha P. Kar; Andrew Berchuck; Simon A. Gayther; Ellen L. Goode; Kirsten B. Moysich; Celeste Leigh Pearce; Susan J. Ramus; Joellen M. Schildkraut; Thomas A. Sellers; Paul D.P. Pharoah
Doi: 10.1158/1055-9965.EPI-17-0315
Yohan Bossé; Christopher I. Amos
Doi: 10.1158/1055-9965.EPI-16-0794
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