Karanth et al. Page 516

Head and Neck cancer mortality differs by race/ethnicity and socioeconomic status (SES). In this study of 76,095 patients, Karanth and colleagues examined the joint association of race/ethnicity and census-tract-level SES with relative survival rates, all-cause and cause-specific mortality. The five-year survival rates differed by race/ethnicity and SES, with non-Hispanic (NH)-Black patients having the lowest. Compared to NH-White patients, NH-Black patients had a higher risk of all-cause and cause-specific mortality, regardless of the SES group. NH-Asian/Pacific Islander and Hispanic patients had higher risk of cause-specific mortality in some SES groups. More research is needed to understand the causes of persistent disparities in head and neck cancer mortalities

Yuan et al. Page 524

Most previous epidemiologic studies evaluating the associations of blood lipids with colorectal cancer risk did not consider the use of cholesterol-lowering medications at the time of lipid measurements, which could bias findings. Leveraging data from the UK Biobank, Yuan and colleagues showed that high total and low-density lipoprotein cholesterols were modestly associated with an elevated risk of colorectal cancer among non-users of cholesterol-lowering medications. This association, however, was not observed among users of these medications. The findings call for careful consideration of cholesterol-lowering medication use in future studies of blood lipids and colorectal cancer risk.

Wang et al. Page 542

This multi-center study of more than 1,000 women with tubo-ovarian high-grade serous carcinoma by Wang and colleagues aimed to understand relationships between tumor methylation signature and time to recurrence/death. In covariate-adjusted analyses at baseline, methylation signature was inversely related to CD8+ tumor-infiltrating lymphocyte levels and TAP1 mRNA expression and was associated with gene expression molecular subtype. Independent of clinical factors, methylation signature was associated with shorter time to recurrence and remained prognostic after adjustment for gene expression molecular subtype and TAP1 mRNA expression. Analyses underscore the importance of DNA methylation in tumor immunosuppressive microenvironments and provide a signature applicable to several methylation interrogation platforms

Mansouri et al. Page 572

Hospitalization rates can be used as an indirect indicator of the burden and severity of adverse health outcomes in childhood cancer survivors (CCS). Using the FCCSS cohort, Mansouri and colleagues found that 5-year-CCS are at higher risk of being hospitalized for renal and urinary disease, particularly renal disease. The results support the need for careful monitoring of long-term renal disease in CCS who have exposures to nephrectomy and especially those treated with high radiation doses (≥20 Gy), even to small kidney volumes. This study provides new evidence with potential impact on surveillance guidelines related to dose-volume indicators associated with renal toxicity in CCS.