African American (AA) women have much higher risk of death from estrogen receptor positive (ER+) breast cancer than non-Hispanic white (Caucasian) women even though these racial groups have same incidence rates. The aim of this study is to explore whether there are racial differences in biological mechanisms that drive ER+ breast cancer and if they might be linked to a higher rate of metastasis and resistance to endocrine therapy. Eligible cases -AA and white women, aged 20-79, with a new diagnosis of stage I-III ER+ breast cancer- were recruited from 3 cancer institutions in Chicago. Control subjects -AA and white women presenting for a screening mammogram without breast symptoms and no history of cancer- have been recruited from the corresponding mammography centers. Serum was collected from AA and white cases and controls in order to conduct a metabolomics and proteomics analysis to identify oncometabolites that might promote aggressive phenotypes in ER/PR breast cancer cells. A follow up on previously established protocol and results from a total of new 266 subjects will be presented.

Citation Format: Ashlie M Santaliz Casiano. Integrated molecular approach to identify biologic factors contributing to breast cancer disparities in Chicago [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr B111.