Background: HPV vaccination is recommended for female and male adolescents in the U.S. to prevent HPV-related cancer, yet the uptake remains suboptimal nationwide. Compared with other racial/ethnic groups, Asian American adolescents have the lowest HPV vaccination rates. Successful HPV vaccine depends heavily on parents' attitudes, perceptions, and willingness to have their adolescents vaccinated.

Objective: This pilot study aimed to examine the intervention effect on the primary outcome of a provider-based, culturally tailored, multilevel intervention to promote HPV vaccination.

Method: A total of 180 parents (110 for intervention group and 70 for control group) with 290 adolescents aged 11 to 18 (170 for intervention group, 120 for control group) were recruited from primary care community health centers in Philadelphia and NYC from 2015 to 2017. Specifically, we compared the uptake of first shot of HPV vaccination at the 6-month post-intervention assessment and completion rate of three shots.

Results: The uptake of at least 1 shot of HPV vaccine was significantly higher among the intervention group (76.36%) than the control (10.00%). The difference between intervention and control group remained statistically significant (odds ratio = .38.47, 95% 13.99 - 105.80) even when we controlled for demographics and health-related covariates, lending support to the significant and strong effects of our intervention on vaccination uptake.

Conclusion: Our finding indicates that provider-based, culturally tailored, multilevel intervention showed promising effect of HPV vaccination uptake among Asian American adolescents. Greater effort and measures are needed for broader implementation of such intervention. Future research is also necessary to explore the application to ethnic minority populations to prevent cancer and reduce health disparities.

Acknowledgement: This project was supported by National Outreach Network (NON) - Community Health Educator (CHE) supplement grant funded by Center for Reduce Cancer Health Disparities (CRCHD)-National Cancer Institute (NCI) (Grant Number: U54CA153513; PI: Grace X. Ma, PhD). The authors wish to thank clinical collaborator Chinatown Medical Services (CMS) and their staff for their support and collaboration.

Citation Format: Grace X. Ma, Shumenghui Zhai, Lin Zhu, Philip Siu, Yin Tan, Sarah Lai, Ivette Astudillo, Safa S. Ibrahim, Ming-Chin Yeh, Min Qi Wang. Promising effects of a culturally tailored multilevel pilot intervention to increase HPV vaccination uptake among Asian American female and male adolescents [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr A029.