Abstract IA12: Variation in genetic ancestry proportions among Latinos and its impact on cancer risk, prediction, and outcomes

Latinos are a heterogeneous group, encompassing individuals with diverse genetic and sociocultural backgrounds. Reports on U.S. cancer incidence rates and cancer mortality in Latinos have only recently started to provide information by national origin, which has unveiled disparities that were not apparent in analyses that grouped all Latinos together. Genetic ancestry is another important factor in the characterization of Latin American populations. Mainly composed of European, Indigenous American and African ancestral influences, it can reflect socioeconomic/sociocultural differences as well as genetic ones. There have been studies testing the association between genetic ancestry and cancer risk, and genetic ancestry and cancer survival. However, there is a lack of published investigations assessing the performance of cancer risk prediction models in Latinos with different ancestry proportions. In this presentation, I will provide an overview of what we know about cancer risk and mortality in Latinos with different ancestry proportions and present preliminary results of an ongoing study of breast cancer risk prediction in U.S. Latinas.

Citation Format: Laura Fejerman. Variation in genetic ancestry proportions among Latinos and its impact on cancer risk, prediction, and outcomes. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr IA12.