Background: Time spent sitting is distinctly different from accumulating too little physical activity and may have independent deleterious effects. Few studies have examined the association between sitting time and site-specific cancer incidence.

Methods: Among 69,260 men and 77,462 women who were cancer-free and enrolled in the American Cancer Society Cancer Prevention Study II Nutrition Cohort, 18,555 men and 12,236 women were diagnosed with cancer between 1992 and 2009. Extended Cox proportional hazards regression was used to estimate multivariable-adjusted relative risks (RR) and 95% confidence intervals (CI) of leisure-time spent sitting with total and site-specific cancer incidence.

Results: Longer leisure-time spent sitting, after adjustment for physical activity, BMI, and other factors, was associated with risk of total cancer in women (RR = 1.10; 95% CI, 1.04–1.17 for ≥6 hours vs. <3 hours per day), but not men (RR = 1.00; 95% CI, 0.96–1.05). In women, sitting time was associated with risk of multiple myeloma (RR = 1.65; 95% CI, 1.07–2.54), invasive breast cancer (RR = 1.10; 95% CI, 1.00–1.21), and ovarian cancer (RR = 1.43; 95% CI, 1.10–1.87). There were no associations between sitting time and site-specific cancers in men.

Conclusion: Longer leisure-time spent sitting was associated with a higher risk of total cancer risk in women, and specifically with multiple myeloma, breast, and ovarian cancers, but sitting time was not associated with cancer risk in men. Further research is warranted to better understand the differences in associations between men and women.

Impact: For women, these findings support American Cancer Society guidelines for cancer prevention to reduce sitting time when possible. Cancer Epidemiol Biomarkers Prev; 24(9); 1350–9. ©2015 AACR.

Over the past few decades, time spent sitting has increased due to technological advancements, transportation, and for other reasons. Sitting time is distinctly different from lack of physical activity and has been associated with greater mortality, cardiovascular disease, type II diabetes mellitus, obesity, and some cancers (1). Sitting time has also been associated with markers of chronic disease risk such as weight gain, high cholesterol, high fasting insulin levels, and other biomarkers (2–5). A recent report concluded that average life expectancy in the U.S. would increase by 2 years if excessive sitting time was reduced by 3 hours per day (6).

Although extensive research supports the role of physical activity in cancer prevention (7), few studies have examined associations between sitting time and site-specific cancer incidence. It is, however, biologically plausible that time spent sitting is a risk factor for cancer due to its effects on increasing adiposity and its impact on metabolic dysfunction (8, 9). A recent meta-analysis (10) examined sedentary time in relation to cancer risk, but evidence was limited for most individual cancer sites because of the few studies that considered any single site and because of differences in the types of sitting time (occupational, television, leisure-time, or total) among studies. Overall, the authors reported that evidence was consistent with a positive association between sitting time and colon and endometrial cancer risk.

Individual reductions in sitting time might be easier to promote and implement during leisure-time. However, further research is needed to clarify the relationship between leisure-time spent sitting specifically and site-specific cancer risk. No previous study has systematically examined leisure-time sitting in relation to site-specific cancer risk. Previous publications from the American Cancer Society's Cancer Prevention Study-II Nutrition Cohort (CPS-IINC; ref. 11) found leisure-time sitting to be positively associated with total cancer mortality in women, but not men, and with multiple myeloma in women (12), ovarian cancer (13), and endometrial cancer (14). Therefore, in the present analysis, we conducted a comprehensive and detailed analysis of sitting time in relation to total cancer incidence, and risk of 17 individual cancer sites in women and 15 cancer sites in men, including those previously examined, with follow-up time extended beyond that included in prior studies from this cohort. Because of the strong relationship between sitting time and weight, we examined the relationship between sitting time and cancer risk with and without adjustment for body mass index (BMI). In addition, we also explored whether the association between sitting time and cancer varies by the level of physical activity or BMI.

Study population

Men and women in this analysis were drawn from the 184,187 participants in the CPS-IINC, a prospective study of cancer incidence and mortality initiated by the American Cancer Society in 1992–93 (15). CPS-IINC members resided in 21 states with population-based state cancer registries and were predominantly 50 to 74 years of age at enrollment when they completed a 10-page mailed questionnaire that included questions on demographic, reproductive, medical, and lifestyle factors. Follow-up questionnaires were mailed every 2 years beginning in 1997 to update exposure information and to ascertain newly diagnosed cancers. The response rate among living participants for each of the follow-up questionnaires was at least 88%. Additional details on the recruitment and characteristics of the CPS-IINC are described elsewhere (15). The Emory University Institutional Review Board approves all aspects of the CPS-IINC.

We excluded sequentially from this analysis men and women who were lost to follow-up (i.e., alive at the first follow-up questionnaire in 1997 but did not return the 1997 or any subsequent follow-up questionnaire; n = 6,251), reported a personal history of cancer at enrollment (n = 21,087), or had missing data on sitting time (n = 4,305), physical activity (n = 3,744), or BMI (n = 2,078) at baseline. After all exclusions, the analytic cohort consisted of 146,722 individuals (69,260 men and 77,462 women) with a mean age of 63.0 (±6.4 SD) at baseline.

Case ascertainment

Between enrollment and June 30, 2009, 18,555 men and 12,236 women were diagnosed with cancer. Of these, 25,057 were initially identified by self-report on a follow-up questionnaire and subsequently verified by medical record (n = 18,736) or through linkage with state cancer registries (n = 6,321; ref. 16). Linkage further identified 299 cancer diagnoses that were not first self-reported. An additional 5,435 participants were identified as having died from cancer through linkage of the cohort with the National Death Index (17). For these cases, death certificates listed cancer as the primary cause of death between the enrollment date and end of follow-up. Of these deaths, 4,202 were subsequently verified through linkage with state cancer registries. Specific causes of cancer were categorized based on the International Classification of Diseases, Ninth or Tenth Revisions (18, 19).

Measures of leisure-time sitting and physical activity

Leisure-time sitting was assessed using the question “during the past year, on an average day, (not counting time spent at your job) how many hours per day did you spend sitting (watching TV, reading, etc.)?” Responses included “none, <3, 3–5, 6–8, >8 hours per day.” Time spent sitting was categorized as 0–<3, 3–5, or ≥6 hours/day.

Information on exercise activity was collected using the question “during the past year, what was the average time per week you spent at the following kinds of activities: walking, jogging/running, lap swimming, tennis or racquetball, bicycling or stationary biking, aerobics/calisthenics, and dancing?” Summary exercise activity MET-hours/week (20) were calculated for each participant with methods described in detail elsewhere (11). Exercise activity was categorized as none, >0–<8.75, 8.75–<17.5, or ≥17.5 MET-hour/week; for reference, 8.75 MET-hours/week is equivalent to meeting current physical activity recommendations of at least 150 minutes/week of moderate-intensity activity.

Other daily-life activities were assessed using the question “during the past year, what was the average time per week you spent at the following kinds of activities: gardening/mowing/planting, heavy housework/vacuuming, heavy home repair/painting, and shopping?” Summary MET-hours/week were calculated (11) and categorized in sex-specific tertiles. Last, light housekeeping was assessed using the question “during the past year, on an average day, (not counting time spent at your job) how many hours per day did you spend light housekeeping?” and categorized as 0–<3, 3–5, or ≥6 hours/day.

Statistical analysis

Sitting time and physical activity were modeled as time-dependent variables and extended Cox proportional hazards regression modeling (21) was used to estimate hazard rate ratios (RR), with follow-up time in days as the time-axis. For each participant, end of follow-up was either (i) diagnosis date, (ii) death date, (iv) date of last survey returned (if the participant did not respond to two sequential follow-up survey cycles), or (iv) June 30, 2009, whichever came first. All models were stratified on exact year of age. Associations of sitting time with cancer incidence were assessed in three models: (i) adjusted for age, (ii) adjusted for age and other potential confounders including physical activity (exercise, daily-life, and light housekeeping), and (iii) additionally adjusted for BMI [weight(kg)/height(m2)]. Potential confounders assessed at baseline included race (white, black, other/unknown), smoking status (lifelong nonsmoker, current smoker, former smoker, ever smoker with unknown status), duration and frequency of smoking among current smokers (≤35, >35 years; <20, ≥20 cigarettes/day), years since quitting among former smokers (≤5, 6–10, 11–15, 16–20, 21–25, >25), BMI (<18.5, 18.5–<25.0, 25.0–<30.0, ≥30.0 kg/m2), education (≤high school, some college/trade school, college graduate), alcohol consumption (nondrinker, <1 drink/day, ≥1 drink/day), total energy intake (calories/day, sex-specific quartiles), red/processed meat intake (grams/week, sex-specific quartiles), family history of cancer, and prevalent chronic disease (included myocardial infarction, stroke, emphysema, hypertension, and high cholesterol) at baseline. Additional covariates were modeled as time dependent and included diabetes, and in women, menopausal status (pre/peri-, post-, and unknown status) and postmenopausal hormone use (never, current, former use). History of mammography screening and hysterectomy and/or oophorectomy was modeled as time dependent in breast cancer models, endoscopy screening in models of colorectal and pancreatic cancers, and PSA testing in models of prostate cancer. Finally, endometrial and ovarian cancer models were restricted to women with an intact uterus or ovaries, respectively.

We examined the combined effects of sitting time and exercise activity by stratifying sitting time on each level of exercise activity with the most exercise activity/least sitting time defining the referent group. Effect modification was assessed by conducting a −2 log likelihood (LL) test comparing a model with multiplicative interaction terms for the combined variables to a reduced model without the interaction terms. P value for statistical interaction was derived from the χ2 distribution of the -2LL test statistic. Effect modification by age at enrollment and BMI was also investigated. For all statistical tests, significance was defined as a P value <0.05. Analyses were conducted using SAS version 9. (SAS Institute Inc.).

This analysis included 69,260 men followed on average of 13.2 years and 77,462 women followed on average for 15.8 years. Men were slightly older, leaner, and more likely to have ever smoked cigarettes compared with women at baseline. Men and women who spent the most leisure-time sitting were more likely to be obese, have type II diabetes mellitus or other chronic diseases, have a higher caloric intake, eat more red/processed meat, and have ever smoked (Tables 1 and 2). Leisure-time sitting did not vary substantially by daily-life or exercise activities. The average total (exercise plus daily-life activities) physical activity among study participants was 26.3 MET-hours/week in men and 25.7 in women, and among those who sat 6 or more hours/day was 25.7 in men and 25.3 in women. The majority of MET-hours were contributed by light intensity activities (e.g., gardening and housework), and walking was the most commonly reported exercise activity with 82% of men and 86% of women reporting some walking.

Table 1.

Baseline characteristics of CPS-II Nutrition Cohort according to leisure-time spent sitting, women

Sitting h/d
<33–5>5
Characteristic(n = 37,131)(n = 32,756)(n = 7,575)
Age 60.9 63.0 63.8 
Total activity MET-h/wk – mean/median 26.3/22.0 25.1/21.5 25.3/20.5 
 Age-adjusted percenta 
Race 
 White 97.3 97.4 96.7 
 Black 1.4 1.5 1.7 
 Other/unknown 1.2 1.1 1.6 
Education 
 High school or less 34.9 38.0 38.3 
 Some college or trade school 31.3 31.7 31.3 
 College graduate 33.1 29.6 29.6 
BMI (kg/m2
 <18.5 2.1 1.6 2.0 
 18.5–<25.0 56.0 47.4 41.5 
 25.0–<30.0 30.0 33.0 32.2 
 ≥30.0 11.9 17.9 24.4 
Alcohol use 
 Nondrinker 45.5 45.1 48.9 
 <1 drink/day 38.5 38.7 34.3 
 ≥ drink/day 11.9 12.8 12.7 
Smoking status 
 Nonsmoker 58.6 52.4 46.4 
 Current smoker 33.4 36.8 39.4 
 Former smoker 6.5 9.7 13.1 
 Ever smoker, status unknown 0.3 0.3 0.4 
Diabetes status 
 No 94.5 93.6 90.9 
 Yes 5.1 6.0 8.7 
Other chronic conditions reportedb 
 None reported 44.3 38.4 35.1 
 Yes 55.7 61.6 64.9 
Exercise activity (MET-h/wk) 
 None 7.9 9.4 14.5 
 <8.75 44.3 46.4 43.1 
 8.75–<17.5 20.5 19.9 18.2 
 ≥17.5 27.2 24.4 24.2 
Daily-life activity (MET-h/wk) 
 T1: <7.0 29.6 30.7 35.1 
 T2: 7.0–<15.5 34.4 33.1 28.5 
 T3: ≥15.5 36.0 36.2 36.3 
Light housekeeping (h/d) 
 <3 63.0 54.8 45.5 
 3–5 27.9 34.0 29.5 
 >5 7.3 9.5 22.6 
Total energy intake (calories per d) 
 Q1: <1,021 24.7 21.9 19.2 
 Q2: 1,021–<1,302 23.4 22.9 20.8 
 Q3: 1,302–<1,633 22.4 23.5 22.5 
 Q4: ≥1633 20.6 24.4 29.2 
Total red meat intake (quartiles-g/wk) 
 Q1: <159.6 25.2 21.1 19.5 
 Q2: 159.6–<293.9 23.4 22.9 21.0 
 Q3: 293.9–<470.2 22.3 23.6 23.4 
 Q4: ≥470.2 20.3 25.2 27.8 
Menopausal status 
 Pre/peri-menopausal 5.7 5.3 5.3 
 Postmenopausal 94.1 94.4 94.4 
Use of postmenopausal hormones 
 Never 42.4 42.7 42.6 
 Current 28.1 27.3 25.6 
 Former 16.4 17.3 18.8 
Hysterectomy and/or oophorectomy 
 No 61.7 61.3 60.3 
 Yes 37.4 37.9 38.5 
Sitting h/d
<33–5>5
Characteristic(n = 37,131)(n = 32,756)(n = 7,575)
Age 60.9 63.0 63.8 
Total activity MET-h/wk – mean/median 26.3/22.0 25.1/21.5 25.3/20.5 
 Age-adjusted percenta 
Race 
 White 97.3 97.4 96.7 
 Black 1.4 1.5 1.7 
 Other/unknown 1.2 1.1 1.6 
Education 
 High school or less 34.9 38.0 38.3 
 Some college or trade school 31.3 31.7 31.3 
 College graduate 33.1 29.6 29.6 
BMI (kg/m2
 <18.5 2.1 1.6 2.0 
 18.5–<25.0 56.0 47.4 41.5 
 25.0–<30.0 30.0 33.0 32.2 
 ≥30.0 11.9 17.9 24.4 
Alcohol use 
 Nondrinker 45.5 45.1 48.9 
 <1 drink/day 38.5 38.7 34.3 
 ≥ drink/day 11.9 12.8 12.7 
Smoking status 
 Nonsmoker 58.6 52.4 46.4 
 Current smoker 33.4 36.8 39.4 
 Former smoker 6.5 9.7 13.1 
 Ever smoker, status unknown 0.3 0.3 0.4 
Diabetes status 
 No 94.5 93.6 90.9 
 Yes 5.1 6.0 8.7 
Other chronic conditions reportedb 
 None reported 44.3 38.4 35.1 
 Yes 55.7 61.6 64.9 
Exercise activity (MET-h/wk) 
 None 7.9 9.4 14.5 
 <8.75 44.3 46.4 43.1 
 8.75–<17.5 20.5 19.9 18.2 
 ≥17.5 27.2 24.4 24.2 
Daily-life activity (MET-h/wk) 
 T1: <7.0 29.6 30.7 35.1 
 T2: 7.0–<15.5 34.4 33.1 28.5 
 T3: ≥15.5 36.0 36.2 36.3 
Light housekeeping (h/d) 
 <3 63.0 54.8 45.5 
 3–5 27.9 34.0 29.5 
 >5 7.3 9.5 22.6 
Total energy intake (calories per d) 
 Q1: <1,021 24.7 21.9 19.2 
 Q2: 1,021–<1,302 23.4 22.9 20.8 
 Q3: 1,302–<1,633 22.4 23.5 22.5 
 Q4: ≥1633 20.6 24.4 29.2 
Total red meat intake (quartiles-g/wk) 
 Q1: <159.6 25.2 21.1 19.5 
 Q2: 159.6–<293.9 23.4 22.9 21.0 
 Q3: 293.9–<470.2 22.3 23.6 23.4 
 Q4: ≥470.2 20.3 25.2 27.8 
Menopausal status 
 Pre/peri-menopausal 5.7 5.3 5.3 
 Postmenopausal 94.1 94.4 94.4 
Use of postmenopausal hormones 
 Never 42.4 42.7 42.6 
 Current 28.1 27.3 25.6 
 Former 16.4 17.3 18.8 
Hysterectomy and/or oophorectomy 
 No 61.7 61.3 60.3 
 Yes 37.4 37.9 38.5 

aAdjusted to the distribution of the CPS-II Nutrition Cohort women.

bPrevalent coronary artery disease, stroke, emphysema, other respiratory disease, hypertension, and high cholesterol.

Table 2.

Baseline characteristics of CPS-II Nutrition Cohort according to leisure-time spent sitting, men

Sitting h/d
<33–5>5
Characteristic(n = 28,410)(n = 30,914)(n = 9,936)
Age 62.9 64.4 65.3 
Total activity MET-h/wk – mean/median 26.8/22.5 26.1/22.5 25.7/22.0 
 Age-adjusted percenta 
Race 
 White 97.4 97.5 97.7 
 Black 1.2 1.2 1.1 
 Other/unknown 1.4 1.3 1.2 
Education 
 High school or less 26.9 27.1 26.1 
 Some college or trade school 24.4 27.5 25.6 
 College graduate 48.1 44.7 47.8 
BMI (kg/m2
 <18.5 0.5 0.5 0.7 
 18.5–<25.0 39.2 33.3 32.3 
 25.0–<30.0 48.7 50.5 48.6 
 ≥30.0 11.6 15.7 18.5 
Alcohol use 
 Nondrinker 32.8 32.5 34.2 
 <1 drink/d 38.9 38.9 36.5 
 ≥ drink/d 24.0 25.3 25.6 
Smoking status 
 Nonsmoker 37.2 29.2 28.2 
 Current smoker 54.8 60.3 58.1 
 Former smoker 7.2 9.8 13.0 
 Ever smoker, status unknown 0.5 0.3 0.4 
Diabetes status 
 No 92.1 90.7 88.0 
 Yes 7.5 9.0 11.6 
Other chronic conditions reportedb 
 None reported 40.8 35.7 33.4 
 Yes 59.2 64.3 66.6 
Exercise (MET-h/wk) 
 None 11.1 12.4 15.8 
 <8.75 37.4 38.6 36.4 
 8.75–<17.5 20.3 19.8 17.9 
 ≥17.5 31.2 29.3 29.8 
Daily-life activity (MET-hs/wk) 
 T1: <6.0 32.8 33.0 39.8 
 T2: 6.0–<15.0 32.1 32.9 27.4 
 T3: ≥15.0 35.1 34.0 32.8 
Light housekeeping (h/d) 
 <3 84.9 83.2 76.0 
 3—5 3.5 5.4 8.7 
 >5 0.5 0.7 4.0 
Total energy intake (calories per d) 
 Q1: <1,357 25.3 22.0 18.7 
 Q2: 1,357–<1,722 23.3 22.8 21.1 
 Q3: 1,722–<2,163 21.6 23.5 23.4 
 Q4: ≥2163 20.3 23.7 27.6 
Total red meat intake (quartiles-g/wk) 
 Q1: <311.9 25.4 21.3 20.2 
 Q2: 311.9–<538.7 22.9 23.0 21.2 
 Q3: 538.7–<835.1 21.8 23.5 23.3 
 Q4: ≥835.1 20.3 24.2 25.9 
Sitting h/d
<33–5>5
Characteristic(n = 28,410)(n = 30,914)(n = 9,936)
Age 62.9 64.4 65.3 
Total activity MET-h/wk – mean/median 26.8/22.5 26.1/22.5 25.7/22.0 
 Age-adjusted percenta 
Race 
 White 97.4 97.5 97.7 
 Black 1.2 1.2 1.1 
 Other/unknown 1.4 1.3 1.2 
Education 
 High school or less 26.9 27.1 26.1 
 Some college or trade school 24.4 27.5 25.6 
 College graduate 48.1 44.7 47.8 
BMI (kg/m2
 <18.5 0.5 0.5 0.7 
 18.5–<25.0 39.2 33.3 32.3 
 25.0–<30.0 48.7 50.5 48.6 
 ≥30.0 11.6 15.7 18.5 
Alcohol use 
 Nondrinker 32.8 32.5 34.2 
 <1 drink/d 38.9 38.9 36.5 
 ≥ drink/d 24.0 25.3 25.6 
Smoking status 
 Nonsmoker 37.2 29.2 28.2 
 Current smoker 54.8 60.3 58.1 
 Former smoker 7.2 9.8 13.0 
 Ever smoker, status unknown 0.5 0.3 0.4 
Diabetes status 
 No 92.1 90.7 88.0 
 Yes 7.5 9.0 11.6 
Other chronic conditions reportedb 
 None reported 40.8 35.7 33.4 
 Yes 59.2 64.3 66.6 
Exercise (MET-h/wk) 
 None 11.1 12.4 15.8 
 <8.75 37.4 38.6 36.4 
 8.75–<17.5 20.3 19.8 17.9 
 ≥17.5 31.2 29.3 29.8 
Daily-life activity (MET-hs/wk) 
 T1: <6.0 32.8 33.0 39.8 
 T2: 6.0–<15.0 32.1 32.9 27.4 
 T3: ≥15.0 35.1 34.0 32.8 
Light housekeeping (h/d) 
 <3 84.9 83.2 76.0 
 3—5 3.5 5.4 8.7 
 >5 0.5 0.7 4.0 
Total energy intake (calories per d) 
 Q1: <1,357 25.3 22.0 18.7 
 Q2: 1,357–<1,722 23.3 22.8 21.1 
 Q3: 1,722–<2,163 21.6 23.5 23.4 
 Q4: ≥2163 20.3 23.7 27.6 
Total red meat intake (quartiles-g/wk) 
 Q1: <311.9 25.4 21.3 20.2 
 Q2: 311.9–<538.7 22.9 23.0 21.2 
 Q3: 538.7–<835.1 21.8 23.5 23.3 
 Q4: ≥835.1 20.3 24.2 25.9 

aAdjusted to the distribution of the CPS-II Nutrition Cohort men.

bPrevalent coronary artery disease, stroke, emphysema, other respiratory disease, hypertension, and high cholesterol.

There was statistically significant heterogeneity in associations of sitting time and total cancer incidence between men and women (P = 0.009); therefore, all analyses were conducted in men and women separately. In women, leisure-time spent sitting was associated with a statistically significant higher risk of total cancer incidence (RR = 1.10; 95% CI, 1.04–1.17 for ≥6 hours vs. <3 hours/day) after adjustment for physical activity, BMI, and other potential confounders (Table 3). When examining site-specific cancer incidence, higher time spent sitting (≥6 hours vs. <3 hours/day) was associated with higher risks of multiple myeloma (RR = 1.65; 95% CI, 1.07–2.54), invasive breast cancer (RR = 1.10; 95% CI, 1.00–1.21), and ovarian cancer (RR = 1.43; 95% CI, 1.10–1.87). The association with endometrial cancer was statistically significant before adjusting for BMI (RR = 1.34; 95% CI, 1.08–1.67), but was attenuated and no longer statistically significant after BMI adjustment (RR = 1.21; 95% CI, 0.97–1.50). Positive associations with head and neck, esophageal, and gallbladder cancers were suggestive, but were not statistically significant.

Table 3.

Relative risks and 95% CIs for sitting time and site-specific cancer incidence in women, 1992–2009

Leisure-time spent sitting (h/d)
Cancer site<33–56 or more
Total cancer Deaths/person-years 5,865/547,569 4,104/363,400 1,603/121,924 
 Age-adj. Ratea 1,096 1,167 1,313 
 MV-adj. RRb (95% CI) 1.00 1.01 (0.97–1.05) 1.12 (1.06–1.19) 
 MV-adj. RRc (95% CI) 1.00 1.01 (0.97–1.05) 1.10 (1.04–1.17) 
Head and neck Deaths/person-years 47/547,569 32/363,400 18/121,924 
 Age-adj. Ratea 15 
 MV-adj. RRb (95% CI) 1.00 0.97 (0.61–1.53) 1.46 (0.84–2.54) 
 MV-adj. RRc (95% CI) 1.00 0.97 (0.61–1.54) 1.49 (0.86–2.61) 
Esophagus Deaths/person-years 22/547,569 16/363,400 7/121,924 
 Age-adj. Ratea 
 MV-adj. RRb (95% CI) 1.00 1.05 (0.54–2.04) 1.14 (0.48–2.74) 
 MV-adj. RRc (95% CI) 1.00 1.06 (0.54–2.05) 1.13 (0.47–2.72) 
Stomach Deaths/person-years 45/547,569 23/363,400 12/121,924 
 Age-adj. Ratea 10 
 MV-adj. RRb (95% CI) 1.00 0.79 (0.47–1.32) 1.02 (0.54–1.96) 
 MV-adj. RRc (95% CI) 1.00 0.80 (0.48–1.34) 1.06 (0.55–2.03) 
Colon and rectumd Deaths/person-years 644/547,569 404/363,400 151/121,924 
 Age-adj. Ratea 123 118 125 
 MV-adj. RRb (95% CI) 1.00 0.90 (0.79–1.02) 0.97 (0.81–1.16) 
 MV-adj. RRc (95% CI) 1.00 0.89 (0.78–1.01) 0.95 (0.79–1.14) 
Liver Deaths/person-years 42/547,569 28/363,400 9/121,924 
 Age-adj. Ratea 
 MV-adj. RRb (95% CI) 1.00 0.94 (0.58–1.54) 0.77 (0.37–1.60) 
 MV-adj. RRc (95% CI) 1.00 0.92 (0.56–1.51) 0.73 (0.35–1.53) 
Gallbladder Deaths/person-years 24/547,569 24/363,400 9/121,924 
 Age-adj. Ratea 
 MV-adj. RRb (95% CI) 1.00 1.53 (0.86–2.75) 1.52 (0.70–3.32) 
 MV-adj. RRc (95% CI) 1.00 1.49 (0.83–2.68) 1.43 (0.65–3.14) 
Pancreasd Deaths/person-years 182/547,569 121/363,400 47/121,924 
 Age-adj. Ratea 36 36 39 
 MV-adj. RRb (95% CI) 1.00 0.97 (0.77–1.23) 1.04 (0.75–1.44) 
 MV-adj. RRc (95% CI) 1.00 0.96 (0.76–1.22) 1.02 (0.73–1.41) 
Lung Deaths/person-years 552/547,569 395/363,400 171/121,924 
 Age-adj. Ratea 106 115 142 
 MV-adj. RRb (95% CI) 1.00 0.92 (0.81–1.05) 0.96 (0.80–1.14) 
 MV-adj. RRc (95% CI) 1.00 0.93 (0.82–1.07) 0.98 (0.82–1.17) 
Melanoma Deaths/person-years 414/547,569 263/363,400 92/121,924 
 Age-adj. Ratea 77 73 76 
 MV-adj. RRb (95% CI) 1.00 0.98 (0.84–1.14) 0.99 (0.78–1.24) 
 MV-adj. RRc (95% CI) 1.00 0.98 (0.84–1.15) 0.99 (0.79–1.25) 
Kidney Deaths/person-years 101/547,569 59/363,400 26/121,924 
 Age-adj. Ratea 19 18 21 
 MV-adj. RRb (95% CI) 1.00 0.91 (0.66–1.27) 1.01 (0.65–1.57) 
 MV-adj. RRc (95% CI) 1.00 0.90 (0.64–1.24) 0.97 (0.62–1.51) 
Bladder Deaths/person-years 126/547,569 109/363,400 36/121,924 
 Age-adj. Ratea 24 32 30 
 MV-adj. RRb (95% CI) 1.00 1.23 (0.94–1.60) 1.17 (0.80–1.70) 
 MV-adj. RRc (95% CI) 1.00 1.23 (0.95–1.60) 1.17 (0.80–1.70) 
Non-Hodgkin lymphoma Deaths/person-years 384/547,569 283/363,400 100/121,924 
 Age-adj. Ratea 73 83 82 
 MV-adj. RRb (95% CI) 1.00 1.13 (0.96–1.32) 1.09 (0.87–1.36) 
 MV-adj. RRc (95% CI) 1.00 1.12 (0.96–1.31) 1.07 (0.86–1.35) 
Multiple myeloma Deaths/person-years 75/547,569 66/363,400 30/121,924 
 Age-adj. Ratea 15 20 25 
 MV-adj. RRb (95% CI) 1.00 1.31 (0.93–1.84) 1.64 (1.06–2.53) 
 MV-adj. RRc (95% CI) 1.00 1.31 (0.93–1.85) 1.65 (1.07–2.54) 
Breaste Deaths/person-years 2,120/547,569 1,490/363,400 555/121,924 
 Age-adj. Ratea 388 410 451 
 MV-adj. RRb (95% CI) 1.00 1.01 (0.95–1.08) 1.12 (1.02–1.24) 
 MV-adj. RRc (95% CI) 1.00 1.00 (0.94–1.07) 1.10 (1.00–1.21) 
Endometriumf Deaths/person-years 372/337,664 292/227,571 112/74,565 
 Age-adj. Rate* 109 132 146 
 MV-adj. RR† (95% CI) 1.00 1.10 (0.94–1.28) 1.34 (1.08–1.67) 
 MV-adj. RR† (95% CI) 1.00 1.04 (0.89–1.22) 1.21 (0.97–1.50) 
Ovaryg Deaths/person-years 231/418,733 193/282,043 77/92,853 
 Age-adj. Ratea 56 70 85 
 MV-adj. RRb (95% CI) 1.00 1.18 (0.97–1.43) 1.42 (1.09–1.85) 
 MV-adj. RRc (95% CI) 1.00 1.18 (0.97–1.44) 1.43 (1.10–1.87) 
All other sites combined Deaths/person-years 613/547,569 413/363,400 175/121,924 
 Age-adj. Ratea 117 122 146 
 MV-adj. RRb (95% CI) 1.00 0.98 (0.87–1.13) 1.21 (1.02–1.44 
 MV-adj. RRc (95% CI) 1.00 0.98 (0.86–1.11) 1.15 (0.97–1.37) 
Leisure-time spent sitting (h/d)
Cancer site<33–56 or more
Total cancer Deaths/person-years 5,865/547,569 4,104/363,400 1,603/121,924 
 Age-adj. Ratea 1,096 1,167 1,313 
 MV-adj. RRb (95% CI) 1.00 1.01 (0.97–1.05) 1.12 (1.06–1.19) 
 MV-adj. RRc (95% CI) 1.00 1.01 (0.97–1.05) 1.10 (1.04–1.17) 
Head and neck Deaths/person-years 47/547,569 32/363,400 18/121,924 
 Age-adj. Ratea 15 
 MV-adj. RRb (95% CI) 1.00 0.97 (0.61–1.53) 1.46 (0.84–2.54) 
 MV-adj. RRc (95% CI) 1.00 0.97 (0.61–1.54) 1.49 (0.86–2.61) 
Esophagus Deaths/person-years 22/547,569 16/363,400 7/121,924 
 Age-adj. Ratea 
 MV-adj. RRb (95% CI) 1.00 1.05 (0.54–2.04) 1.14 (0.48–2.74) 
 MV-adj. RRc (95% CI) 1.00 1.06 (0.54–2.05) 1.13 (0.47–2.72) 
Stomach Deaths/person-years 45/547,569 23/363,400 12/121,924 
 Age-adj. Ratea 10 
 MV-adj. RRb (95% CI) 1.00 0.79 (0.47–1.32) 1.02 (0.54–1.96) 
 MV-adj. RRc (95% CI) 1.00 0.80 (0.48–1.34) 1.06 (0.55–2.03) 
Colon and rectumd Deaths/person-years 644/547,569 404/363,400 151/121,924 
 Age-adj. Ratea 123 118 125 
 MV-adj. RRb (95% CI) 1.00 0.90 (0.79–1.02) 0.97 (0.81–1.16) 
 MV-adj. RRc (95% CI) 1.00 0.89 (0.78–1.01) 0.95 (0.79–1.14) 
Liver Deaths/person-years 42/547,569 28/363,400 9/121,924 
 Age-adj. Ratea 
 MV-adj. RRb (95% CI) 1.00 0.94 (0.58–1.54) 0.77 (0.37–1.60) 
 MV-adj. RRc (95% CI) 1.00 0.92 (0.56–1.51) 0.73 (0.35–1.53) 
Gallbladder Deaths/person-years 24/547,569 24/363,400 9/121,924 
 Age-adj. Ratea 
 MV-adj. RRb (95% CI) 1.00 1.53 (0.86–2.75) 1.52 (0.70–3.32) 
 MV-adj. RRc (95% CI) 1.00 1.49 (0.83–2.68) 1.43 (0.65–3.14) 
Pancreasd Deaths/person-years 182/547,569 121/363,400 47/121,924 
 Age-adj. Ratea 36 36 39 
 MV-adj. RRb (95% CI) 1.00 0.97 (0.77–1.23) 1.04 (0.75–1.44) 
 MV-adj. RRc (95% CI) 1.00 0.96 (0.76–1.22) 1.02 (0.73–1.41) 
Lung Deaths/person-years 552/547,569 395/363,400 171/121,924 
 Age-adj. Ratea 106 115 142 
 MV-adj. RRb (95% CI) 1.00 0.92 (0.81–1.05) 0.96 (0.80–1.14) 
 MV-adj. RRc (95% CI) 1.00 0.93 (0.82–1.07) 0.98 (0.82–1.17) 
Melanoma Deaths/person-years 414/547,569 263/363,400 92/121,924 
 Age-adj. Ratea 77 73 76 
 MV-adj. RRb (95% CI) 1.00 0.98 (0.84–1.14) 0.99 (0.78–1.24) 
 MV-adj. RRc (95% CI) 1.00 0.98 (0.84–1.15) 0.99 (0.79–1.25) 
Kidney Deaths/person-years 101/547,569 59/363,400 26/121,924 
 Age-adj. Ratea 19 18 21 
 MV-adj. RRb (95% CI) 1.00 0.91 (0.66–1.27) 1.01 (0.65–1.57) 
 MV-adj. RRc (95% CI) 1.00 0.90 (0.64–1.24) 0.97 (0.62–1.51) 
Bladder Deaths/person-years 126/547,569 109/363,400 36/121,924 
 Age-adj. Ratea 24 32 30 
 MV-adj. RRb (95% CI) 1.00 1.23 (0.94–1.60) 1.17 (0.80–1.70) 
 MV-adj. RRc (95% CI) 1.00 1.23 (0.95–1.60) 1.17 (0.80–1.70) 
Non-Hodgkin lymphoma Deaths/person-years 384/547,569 283/363,400 100/121,924 
 Age-adj. Ratea 73 83 82 
 MV-adj. RRb (95% CI) 1.00 1.13 (0.96–1.32) 1.09 (0.87–1.36) 
 MV-adj. RRc (95% CI) 1.00 1.12 (0.96–1.31) 1.07 (0.86–1.35) 
Multiple myeloma Deaths/person-years 75/547,569 66/363,400 30/121,924 
 Age-adj. Ratea 15 20 25 
 MV-adj. RRb (95% CI) 1.00 1.31 (0.93–1.84) 1.64 (1.06–2.53) 
 MV-adj. RRc (95% CI) 1.00 1.31 (0.93–1.85) 1.65 (1.07–2.54) 
Breaste Deaths/person-years 2,120/547,569 1,490/363,400 555/121,924 
 Age-adj. Ratea 388 410 451 
 MV-adj. RRb (95% CI) 1.00 1.01 (0.95–1.08) 1.12 (1.02–1.24) 
 MV-adj. RRc (95% CI) 1.00 1.00 (0.94–1.07) 1.10 (1.00–1.21) 
Endometriumf Deaths/person-years 372/337,664 292/227,571 112/74,565 
 Age-adj. Rate* 109 132 146 
 MV-adj. RR† (95% CI) 1.00 1.10 (0.94–1.28) 1.34 (1.08–1.67) 
 MV-adj. RR† (95% CI) 1.00 1.04 (0.89–1.22) 1.21 (0.97–1.50) 
Ovaryg Deaths/person-years 231/418,733 193/282,043 77/92,853 
 Age-adj. Ratea 56 70 85 
 MV-adj. RRb (95% CI) 1.00 1.18 (0.97–1.43) 1.42 (1.09–1.85) 
 MV-adj. RRc (95% CI) 1.00 1.18 (0.97–1.44) 1.43 (1.10–1.87) 
All other sites combined Deaths/person-years 613/547,569 413/363,400 175/121,924 
 Age-adj. Ratea 117 122 146 
 MV-adj. RRb (95% CI) 1.00 0.98 (0.87–1.13) 1.21 (1.02–1.44 
 MV-adj. RRc (95% CI) 1.00 0.98 (0.86–1.11) 1.15 (0.97–1.37) 

aRate per 100,000 standardized to the age-adjusted distribution of the CPS-II population.

bAdjusted for physical activity (exercise, daily-life, and light housekeeping), race, smoking status, duration and frequency of smoking among current smokers, years since quitting among former smokers, education, alcohol consumption, total energy intake, red/processed meat intake, family history of cancer, prevalent chronic disease, diabetes, menopausal status, and postmenopausal hormone use.

cAdditional adjustment for BMI.

dAlso adjusted for endoscopy screening.

eAlso adjusted for history of mammography screening and hysterectomy and/or oophorectomy.

fExcluded women without an intact uterus.

gExcluded women without ovaries.

In women, sitting 6 or more hours/day was statistically significantly associated with overall cancer among the most active (RR = 1.14; 95% CI, 1.03–1.27), and least active women (RR = 1.13; 95% CI, 1.04–1.23), but not among the moderately active (RR = 1.04; 95% CI, 0.92–1.17) relative to more physically active women reporting <3 hours/day of sitting, although, statistical interaction was not apparent (P = 0.16). Exercise activity, BMI, and age did not modify associations of sitting time with total or site-specific cancer risk (data not shown).

In men, leisure-time spent sitting was not associated with total cancer incidence (RR = 1.00; 95% CI, 0.96–1.05 for ≥6 hours vs. <3 hours/day; Table 4). Multivariable-adjusted results were similar with or without adjustment for BMI. There were null associations of leisure-time spent sitting with risk of all site-specific cancers; however, RRs of sitting time with risk of head and neck, gallbladder, and pancreatic cancers were higher than one (P < 0.1; Table 4). Although there was evidence that sitting 3 to 5 hours/day was associated with a lower risk of total prostate cancer compared with sitting <3 hours per day, there was no evidence of a dose response, and this association was attenuated when limited to advanced prostate cancer.

Table 4.

Relative risks and 95% confidence intervals for sitting time and site-specific cancer incidence in men, 1992–2009

Leisure-time spent sitting (h/d)
Cancer site<33–56 or more
Total cancer Deaths/person-years 7,762/366,814 6,792/308,731 2,959/128,206 
 Age-adj. Ratea 2,197 2,287 2,314 
 MV-adj. RRb (95% CI) 1.00 (ref) 0.99 (0.96–1.03) 1.00 (0.96–1.05) 
 MV-adj. RRc (95% CI) 1.00 (ref) 0.99 (0.96–1.03) 1.00 (0.96–1.05) 
Head and neck Deaths/person-years 109/366,814 107/308,731 58/128,206 
 Age-adj. Ratea 30 36 45 
 MV-adj. RRb (95% CI) 1.00 1.04 (0.79–1.36) 1.22 (0.88–1.69) 
 MV-adj. RRc (95% CI) 1.00 1.04 (0.79–1.37) 1.22 (0.88–1.69) 
Esophagus Deaths/person-years 119/366,814 102/308,731 49/128,206 
 Age-adj. Ratea 34 34 38 
 MV-adj. RRb (95% CI) 1.00 0.97 (0.74–1.27) 1.05 (0.75–1.48) 
 MV-adj. RRc (95% CI) 1.00 0.96 (0.73–1.26) 1.04 (0.74–1.46) 
Stomach Deaths/person-years 89/366,814 101/308,731 36/128,206 
 Age-adj. Ratea 26 36 28 
 MV-adj. RRb (95% CI) 1.00 1.23 (0.92–1.65) 1.04 (0.70–1.55) 
 MV-adj. RRc (95% CI) 1.00 1.23 (0.92–1.65) 1.05 (0.71–1.55) 
Colon and rectumd Deaths/person-years 646/366,814 553/308,731 248/128/206 
 Age-adj. Ratea 182 186 194 
 MV-adj. RRb (95% CI) 1.00 0.96 (0.85–1.07) 1.03 (0.89–1.19) 
 MV-adj. RRc (95% CI) 1.00 0.95 (0.84–1.07) 1.01 (0.87–1.18) 
Liver Deaths/person-years 82/366,814 59/308,731 30/128,206 
 Age-adj. Ratea 24 21 23 
 MV-adj. RRb (95% CI) 1.00 0.76 (0.54–1.07) 0.84 (0.55–1.29) 
 MV-adj. RRc (95% CI) 1.00 0.75 (0.53–1.06) 0.83 (0.54–1.28) 
Gallbladder Deaths/person-years 12/366,816 12/308,731 9/128,206 
 Age-adj. Ratea 
 MV-adj. RRb (95% CI) 1.00 1.21 (0.54–2.74) 2.14 (0.89–5.16) 
 MV-adj. RRc (95% CI) 1.00 1.19 (0.53–2.69) 2.11 (0.87–5.09) 
Pancreasd Deaths/person-years 178/366,814 165/308,731 82/128,206 
 Age-adj. Ratea 52 59 66 
 MV-adj. RRb (95% CI) 1.00 1.07 (0.86–1.33) 1.17 (0.89–1.53) 
 MV-adj. RRc (95% CI) 1.00 1.06 (0.85–1.31) 1.14 (0.87–1.49) 
Lung Deaths/person-years 775/366,814 772/308,731 356/128,206 
 Age-adj. Ratea 224 260 279 
 MV-adj. RRb (95% CI) 1.00 1.02 (0.92–1.13) 1.01 (0.89–1.15) 
 MV-adj. RRc (95% CI) 1.00 1.03 (0.93–1.14) 1.01 (0.89–1.15) 
Melanoma Deaths/person-years 494/366,814 466/308,731 194/128,206 
 Age-adj. Ratea 139 158 153 
 MV-adj. RRb (95% CI) 1.00 1.10 (0.96–1.25) 1.05 (0.89–1.24) 
 MV-adj. RRc (95% CI) 1.00 1.10 (0.96–1.25) 1.05 (0.88–1.24) 
Kidney Deaths/person-years 141/366,814 179/308,731 59/128,206 
 Age-adj. Ratea 40 61 47 
 MV-adj. RRb (95% CI) 1.00 1.49 (1.19–1.86) 1.11 (0.82–1.52) 
 MV-adj. RRc (95% CI) 1.00 1.47 (1.17–1.84) 1.09 (0.80–1.48) 
Bladder Deaths/person-years 541/366,814 435/308,731 211/128,206 
 Age-adj. Ratea 160 150 168 
 MV-adj. RRb (95% CI) 1.00 0.94 (0.83–1.08) 1.01 (0.86–1.19) 
 MV-adj. RRc (95% CI) 1.00 0.94 (0.83–1.07) 1.01 (0.86–1.19) 
Non-Hodgkin lymphoma Deaths/person-years 415/366,814 389/308,731 157/128,206 
 Age-adj. Ratea 118 135 125 
 MV-adj. RRb (95% CI) 1.00 1.13 (0.98–1.30) 1.05 (0.87–1.26) 
 MV-adj. RRc (95% CI) 1.00 1.12 (0.97–1.29) 1.04 (0.86–1.25) 
Multiple myeloma Deaths/person-years 104/366,814 101/308,731 38/128,206 
 Age-adj. Ratea 30 34 32 
 MV-adj. RRb (95% CI) 1.00 1.15 (0.87–1.52) 1.02 (0.70–1.48) 
 MV-adj. RRc (95% CI) 1.00 1.14 (0.86–1.50) 1.00 (0.68–1.45) 
Prostatee Deaths/person-years 3,782/366,814 3,157/308,731 1,337/128,206 
 Age-adj. Ratea 1,054 1,038 1,029 
 MV-adj. RRb (95% CI) 1.00 0.94 (0.90–0.99) 0.96 (0.90–1.02) 
 MV-adj. RRc (95% CI) 1.00 0.94 (0.90–0.99) 0.97 (0.91–1.03) 
Advanced prostatee Deaths/person-years 785/366,814 652/308,731 268/128,206 
 Age-adj. Ratea 218 215 210 
 MV-adj. RRb (95% CI) 1.00 0.95 (0.86–1.04) 0.96 (0.85–1.09) 
 MV-adj. RRc (95% CI) 1.00 0.95 (0.86–1.04) 0.96 (0.85–1.09) 
All other sites combined Deaths/person-years 640/366,814 576/308,731 254/128,106 
 Age-adj. Ratea 183 199 202 
 MV-adj. RRb (95% CI) 1.00 1.03 (0.92–1.15) 1.03 (0.89–1.20) 
 MV-adj. RRc (95% CI) 1.00 1.03 (0.92–1.15) 1.03 (0.89–1.19) 
Leisure-time spent sitting (h/d)
Cancer site<33–56 or more
Total cancer Deaths/person-years 7,762/366,814 6,792/308,731 2,959/128,206 
 Age-adj. Ratea 2,197 2,287 2,314 
 MV-adj. RRb (95% CI) 1.00 (ref) 0.99 (0.96–1.03) 1.00 (0.96–1.05) 
 MV-adj. RRc (95% CI) 1.00 (ref) 0.99 (0.96–1.03) 1.00 (0.96–1.05) 
Head and neck Deaths/person-years 109/366,814 107/308,731 58/128,206 
 Age-adj. Ratea 30 36 45 
 MV-adj. RRb (95% CI) 1.00 1.04 (0.79–1.36) 1.22 (0.88–1.69) 
 MV-adj. RRc (95% CI) 1.00 1.04 (0.79–1.37) 1.22 (0.88–1.69) 
Esophagus Deaths/person-years 119/366,814 102/308,731 49/128,206 
 Age-adj. Ratea 34 34 38 
 MV-adj. RRb (95% CI) 1.00 0.97 (0.74–1.27) 1.05 (0.75–1.48) 
 MV-adj. RRc (95% CI) 1.00 0.96 (0.73–1.26) 1.04 (0.74–1.46) 
Stomach Deaths/person-years 89/366,814 101/308,731 36/128,206 
 Age-adj. Ratea 26 36 28 
 MV-adj. RRb (95% CI) 1.00 1.23 (0.92–1.65) 1.04 (0.70–1.55) 
 MV-adj. RRc (95% CI) 1.00 1.23 (0.92–1.65) 1.05 (0.71–1.55) 
Colon and rectumd Deaths/person-years 646/366,814 553/308,731 248/128/206 
 Age-adj. Ratea 182 186 194 
 MV-adj. RRb (95% CI) 1.00 0.96 (0.85–1.07) 1.03 (0.89–1.19) 
 MV-adj. RRc (95% CI) 1.00 0.95 (0.84–1.07) 1.01 (0.87–1.18) 
Liver Deaths/person-years 82/366,814 59/308,731 30/128,206 
 Age-adj. Ratea 24 21 23 
 MV-adj. RRb (95% CI) 1.00 0.76 (0.54–1.07) 0.84 (0.55–1.29) 
 MV-adj. RRc (95% CI) 1.00 0.75 (0.53–1.06) 0.83 (0.54–1.28) 
Gallbladder Deaths/person-years 12/366,816 12/308,731 9/128,206 
 Age-adj. Ratea 
 MV-adj. RRb (95% CI) 1.00 1.21 (0.54–2.74) 2.14 (0.89–5.16) 
 MV-adj. RRc (95% CI) 1.00 1.19 (0.53–2.69) 2.11 (0.87–5.09) 
Pancreasd Deaths/person-years 178/366,814 165/308,731 82/128,206 
 Age-adj. Ratea 52 59 66 
 MV-adj. RRb (95% CI) 1.00 1.07 (0.86–1.33) 1.17 (0.89–1.53) 
 MV-adj. RRc (95% CI) 1.00 1.06 (0.85–1.31) 1.14 (0.87–1.49) 
Lung Deaths/person-years 775/366,814 772/308,731 356/128,206 
 Age-adj. Ratea 224 260 279 
 MV-adj. RRb (95% CI) 1.00 1.02 (0.92–1.13) 1.01 (0.89–1.15) 
 MV-adj. RRc (95% CI) 1.00 1.03 (0.93–1.14) 1.01 (0.89–1.15) 
Melanoma Deaths/person-years 494/366,814 466/308,731 194/128,206 
 Age-adj. Ratea 139 158 153 
 MV-adj. RRb (95% CI) 1.00 1.10 (0.96–1.25) 1.05 (0.89–1.24) 
 MV-adj. RRc (95% CI) 1.00 1.10 (0.96–1.25) 1.05 (0.88–1.24) 
Kidney Deaths/person-years 141/366,814 179/308,731 59/128,206 
 Age-adj. Ratea 40 61 47 
 MV-adj. RRb (95% CI) 1.00 1.49 (1.19–1.86) 1.11 (0.82–1.52) 
 MV-adj. RRc (95% CI) 1.00 1.47 (1.17–1.84) 1.09 (0.80–1.48) 
Bladder Deaths/person-years 541/366,814 435/308,731 211/128,206 
 Age-adj. Ratea 160 150 168 
 MV-adj. RRb (95% CI) 1.00 0.94 (0.83–1.08) 1.01 (0.86–1.19) 
 MV-adj. RRc (95% CI) 1.00 0.94 (0.83–1.07) 1.01 (0.86–1.19) 
Non-Hodgkin lymphoma Deaths/person-years 415/366,814 389/308,731 157/128,206 
 Age-adj. Ratea 118 135 125 
 MV-adj. RRb (95% CI) 1.00 1.13 (0.98–1.30) 1.05 (0.87–1.26) 
 MV-adj. RRc (95% CI) 1.00 1.12 (0.97–1.29) 1.04 (0.86–1.25) 
Multiple myeloma Deaths/person-years 104/366,814 101/308,731 38/128,206 
 Age-adj. Ratea 30 34 32 
 MV-adj. RRb (95% CI) 1.00 1.15 (0.87–1.52) 1.02 (0.70–1.48) 
 MV-adj. RRc (95% CI) 1.00 1.14 (0.86–1.50) 1.00 (0.68–1.45) 
Prostatee Deaths/person-years 3,782/366,814 3,157/308,731 1,337/128,206 
 Age-adj. Ratea 1,054 1,038 1,029 
 MV-adj. RRb (95% CI) 1.00 0.94 (0.90–0.99) 0.96 (0.90–1.02) 
 MV-adj. RRc (95% CI) 1.00 0.94 (0.90–0.99) 0.97 (0.91–1.03) 
Advanced prostatee Deaths/person-years 785/366,814 652/308,731 268/128,206 
 Age-adj. Ratea 218 215 210 
 MV-adj. RRb (95% CI) 1.00 0.95 (0.86–1.04) 0.96 (0.85–1.09) 
 MV-adj. RRc (95% CI) 1.00 0.95 (0.86–1.04) 0.96 (0.85–1.09) 
All other sites combined Deaths/person-years 640/366,814 576/308,731 254/128,106 
 Age-adj. Ratea 183 199 202 
 MV-adj. RRb (95% CI) 1.00 1.03 (0.92–1.15) 1.03 (0.89–1.20) 
 MV-adj. RRc (95% CI) 1.00 1.03 (0.92–1.15) 1.03 (0.89–1.19) 

aRate per 100,000 standardized to the age-adjusted distribution of the CPS-II population.

bAdjusted for physical activity (exercise, daily-life, and light housekeeping), race, smoking status, duration and frequency of smoking among current smokers, years since quitting among former smokers, education, alcohol consumption, total energy intake, red/processed meat intake, family history of cancer, prevalent chronic disease, and diabetes.

cAdditional adjustment for BMI.

dAlso adjusted for endoscopy screening.

eAlso adjusted for PSA testing.

The null associations for sitting time and cancer risk for men persisted among all categories of exercise activity and age (data not shown); however, there was some evidence that associations may differ by BMI (interaction P = 0.04): sitting time 6 or more hours compared with <3 hours/day was marginally associated with cancer risk in obese men (RR = 1.11; 95% CI, 1.00–1.24) but not in normal weight (RR = 0.97; 95% CI, 0.90–1.05) or overweight (RR = 0.99; 95% CI, 0.93–1.05) men.

In a sensitivity analysis, cases that occurred in the first year of follow-up were excluded due to the potential of reverse causality, and results remained unchanged (data not shown).

The present study is the first to comprehensively examine leisure-time spent sitting in relation to total and site-specific cancer incidence. Women who reported sitting for more than 6 versus less than 3 hours/day during their leisure-time had a 10% higher risk of all cancers combined. Leisure-time sitting was not associated with cancer risk in men with the exception of an 11% higher risk associated with sitting time among obese men. In both men and women, associations were not modified by physical activity or age.

To our knowledge, no previous studies examined associations between leisure-time sitting and total cancer incidence. However, many studies examined leisure-time sitting in relation to cancer mortality (11, 22–27). Of these, three reported statistically significant positive associations, including an earlier analysis from the CPS-IINC. Consistent with the findings reported herein for cancer incidence, in the earlier CPS-II analysis, sitting time was associated with cancer mortality in women only; in contrast, the other two studies reported positive associations in men and women (25, 26).

Sitting time has been studied using various domains such as occupational, leisure, or total time, which has implications for comparing study results. A recent meta-analysis, including 21 prospective cohorts and 22 case–control studies, examined sitting time in relation to site-specific cancer risk (10), but approximately half of those studies examined occupational sitting time, and there were few studies in relation to any individual cancer site. On the basis of the limited evidence available, it was concluded that sitting time was associated with higher colon and endometrial cancer risks. Although we did not observe an association with colon cancer, few previous studies have examined this association, and most previous studies reporting a positive association specifically examined television time (28, 29) or occupational sitting (30–33). While one of these studies (28) also reported an association with total sitting time, risk was greatly attenuated compared to risk associated with television watching.

In this study, leisure-time spent sitting was statistically significantly associated with endometrial cancer prior to adjustment for BMI, but this association was attenuated and no longer statistically significant after including BMI in the model. Similarly, higher risks without adjusting for BMI were previously reported in the CPS-IINC based on 11 years of follow-up (14) and in two other prospective cohorts (34, 35). Collectively, these findings suggest that the association between sitting time and endometrial cancer incidence might be confounded or mediated by BMI.

Sitting time was also associated with higher risks of invasive breast and ovarian cancers and with multiple myeloma in women. Previously published findings from the CPS-IINC (12, 13) showed similar results for ovarian cancer and multiple myeloma, but were based on fewer numbers of incident cancers and shorter follow-up time (9 and years, respectively). In the previous CPS-IINC study of breast cancer based on 15 years of follow-up (36), we showed no association with sitting time, but unlike the present analysis which was restricted to invasive breast cancer, in situ breast cancers were included. Only one other prospective study examined invasive breast cancer (31), and showed a borderline higher association, similar in magnitude to this study, with total sitting; thus a higher, albeit modest, risk with leisure-time sitting and invasive breast cancer cannot be ruled out.

The previous CPS-IINC study and one case–control study reported a higher risk between leisure-time sitting and ovarian cancer (37), whereas two studies of occupational (38, 39) and one of total (40) sitting time were null. The only other study of multiple myeloma remains the earlier analysis in the CPS-IINC (12), and results were similar to the present findings. This analysis extends follow-up time for the previously examined cancer sites, and examines 13 additional individual cancer sites and total cancer in women.

The lower risk of prostate cancer among men who sat 3 to 5 hours per day was similar to the inverse association observed in another large prospective cohort (41). However, in both studies, there was no dose–response relationship, and results were attenuated when restricted to advanced prostate cancer only. Thus, based on the limited studies to date, it is unclear whether sitting time is associated with prostate cancer risk. No additional site-specific cancers were associated with leisure-time spent sitting in men or women, although there was a suggestion of an association with head and neck and gallbladder cancer in men and women, esophageal cancer in women, and pancreatic cancer in men.

Several factors could explain a positive association between time sitting and cancer risk. Time spent sitting might be associated with other unhealthy behaviors that are not captured or are incompletely captured through questionnaires. Sitting time may also represent a different behavior than physical inactivity as it has important independent metabolic consequences that may be associated with cancer risk. Laboratory animal and human intervention studies have shown that high sedentary time is associated with higher fasting glucose and other aspects of metabolic dysfunction (reviewed in ref. 8). Sitting time may also displace physical activity which would result in an overall decrease in energy expenditure; for example, many individuals who meet physical activity recommendations spend much of their remaining time sitting in the car, at work, or at home.

In addition, substantial evidence from observational studies and randomized clinical trials shows that reducing time sitting lowers risk of obesity and type II diabetes mellitus, two important risk factors for many cancers (42–46). Residual confounding by excess body weight could contribute to the association between sitting time and cancer risk; however, we also adjusted for BMI using a continuous variable and results were unchanged. High BMI also may be on the causal pathway between longer sitting time and cancer risk (47), but associations at all sites in women except the endometrium were only slightly attenuated by controlling for or stratifying on BMI. Thus, the association between sitting time and cancer risk is unlikely to be explained by BMI alone. In contrast, the positive association with leisure-time sitting in men was limited to obese men. It is plausible that the metabolic alterations due to leisure-time spent sitting are not substantial enough to affect cancer risk in normal weight men or that there remains some residual confounding by obesity, or other factors, in men.

Strengths of our study include its large sample size including over 30,000 incident cancers, prospective design, and ability to control for many cancer risk factors, including physical activity and BMI. The lack of occupational data is a limitation and may lead to some misclassification of total sitting time. However, this is likely to have minimal impact, in particular for women, because the majority (80%) of female participants in CPS-IINC were retired or homemakers at baseline, and among those not retired, very few women worked in jobs that involved any activity (7%). Thus, for women, leisure-time spent sitting likely reflects the majority of their total sitting time. In contrast, the lack of occupational physical activity data may be a broader limitation in men. Although the majority of men were also retired or homemakers (57%), and among those who worked, few had active jobs (21%), reliance on leisure-time sitting and no occupational sitting data may lead to greater misclassification of total sitting time in men than women. Another limitation is the use of self-reported measures of sitting time and physical activity. Although physical activity and sitting time are subject to misreporting and were not directly validated in this study, they are very similar to those used and validated in another prospective study (48) and have also been associated with total mortality (11), weight gain in women (47), and various cancers in this cohort (12–14, 36).

In conclusion, longer leisure-time spent sitting was associated with a modest risk of cancer in women, and specifically with breast and ovarian cancers, and multiple myeloma. Sitting time was also associated with endometrial cancer risk; however, unlike other observed associations, this association appeared to be confounded or perhaps mediated by body weight. In contrast, leisure-time spent sitting was associated with overall cancer risk only among obese men. Given the prevalence of time spent sitting in the United States, even a modest positive association can have broad public health implications. However, further research is warranted to better understand the differences in associations between men and women.

No potential conflicts of interest were disclosed.

Conception and design: A.V. Patel, P.T. Campbell, S.M. Gapstur

Development of methodology: A.V. Patel, P.T. Campbell

Acquisition of data (provided animals, acquired and managed patients, provided facilities, etc.): A.V. Patel, P.T. Campbell, S.M. Gapstur

Analysis and interpretation of data (e.g., statistical analysis, biostatistics, computational analysis): A.V. Patel, J.S. Hildebrand, P.T. Campbell, S.M. Gapstur

Writing, review, and/or revision of the manuscript: A.V. Patel, J.S. Hildebrand, P.T. Campbell, L.R. Teras, L.L. Craft, M.L. McCullough, S.M. Gapstur

Other (provided expertise related to physical activity and sedentary behavior constructs in the paper): L.L. Craft

The authors would like to acknowledge the contribution to this study from central cancer registries supported through the Centers for Disease Control and Prevention National Program of Cancer Registries, and cancer registries supported by the National Cancer Institute Surveillance, Epidemiology, and End Results program.

This work was supported by the American Cancer Society, which funds the creation, maintenance, and updating of the Cancer Prevention Study-II cohort.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

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