There is no formal community-wide melanoma screening program in Australia, but the importance of early detection and regular skin self-examination is generally well understood. It is important that individuals are able to identify key melanoma risk factors so that those at high risk can modify their sun-related behaviours and take appropriate preventative actions from a young age. Aims: 1) To evaluate the accuracy of self-reported pigmentation and nevus phenotype compared to clinical assessment, and 2) to examine agreement between clinically-measured whole-body nevus count and clinically-measured nevus count on selected anatomical regions, given that localised mole count is often used as a proxy measure. Methods: The sample included 456 cases with invasive cutaneous melanoma diagnosed between ages 18–39 years and 538 controls from the population-based Australian Melanoma Family Study. Participants completed a questionnaire regarding their pigmentation and nevus phenotype, and attended a clinical skin examination with a dermatologic trainee. Results: There was strong agreement between self-reported and clinical measurement for eye color (weighted kappa, Kw, = 0.83, 95% confidence interval (CI) 0.80–0.86); and moderate agreement for hair color (Kw = 0.52, 95% CI 0.47–0.56) There was poor agreement for skin color when using spectrophotometer-derived individual typography angle (ITA) scores as the objective measure (Kw = 0.18, 95% CI 0.14–0.22). Participants underestimated their nevus counts. The Spearman correlation was 0.43 (95% CI 0.38–0.49) when comparing clinically-measured total body nevus count (≥2 mm) with self-reported nevus density categories, and the intraclass correlation was 0.36 (95% CI 0.30–0.41) when comparing nevus counts on the back. There was good agreement between quartile distributions of clinically-measured site-specific nevus counts with total body nevus counts, particularly for the arms (Kw = 0.76 for men and 0.80 for women). Conclusions: Agreement between self-reported pigmentation and nevus phenotype compared to clinical assessment ranges from poor to excellent, depending on the measure. For studies where a full body nevus count is impractical, measuring nevus counts on the arms would be an acceptable alternative.
The following are the 16 highest scoring abstracts of those submitted for presentation at the 38th Annual ASPO meeting held March 9–11, 2014, in Arlington, VA.