Abstract A70: Incidence of cancer among Hispanics with AIDS compared with the general population in Puerto Rico: 1987–2003

Puerto Rico (PR) ranks among the top US states and territories with the highest number of AIDS cases. Puerto Ricans are also a minority group with one of the highest mortality rates in the US. However, the risk of cancer among Hispanics living in the US or PR has not been well described. The purpose of this study was to determine the incidence and prevalence of AIDS defining and non-AIDS defining cancers among Hispanics with AIDS in PR. A probabilistic matching algorithm was used to link the PR AIDS Surveillance and PR Central Cancer Registry databases using name, social security number, sex, and date of birth. AIDS cases were grouped according to year of AIDS onset and antiretroviral therapy (ART) availability: 1987–1989 (limited availability), 1990–1995 (mono and dual therapy), and 1996–2002 (HAART). From a total of 634 cancers identified 66.7% were AIDS defining and 33.3% were non-AIDS defining. The number of cancers according to ART availability period was 68, 381, and 185, respectively. The standardized incidence ratio (SIR) during the period from 1996–2003 for the following non-AIDS defining cancers was significantly higher in the AIDS population than in the general population: anal (SIR, 41.9 [95% CI, 15.0 – 91.0]), Hodgkin lymphoma (SIR, 22.2 [CI, 7.2 – 52.0]), larynx (SIR, 11.7 [CI, 3.2 – 30.0]), liver (SIR, 14.6 [CI, 5.9 – 30.0]), oropharyngeal (SIR, 12.9 [CI, 6.4 – 23.0]), and vaginal (SIR, 47.1 [CI, 9.7 – 140.0). Hispanics with AIDS consistently showed a greater incidence of non-AIDS related cancers compared to the general population in PR and that has not changed over time.