Abstract A61: Analysis of 8q prostate cancer risk locus in the Afro-Barbadian population

The 8q24 genomic interval has been implicated in prostate cancer risk and has been universally replicable. Importantly the region has been replicated in African American prostate cancer cohorts as well; however little or no work has been done in African populations outside of the US. We have genotyped 13 known genetic variants at 8q24 in a cohort of 650 sporadic prostate cancer cases and 700 matched controls from the island country of Barbados. Although our group has previously determined European admixture estimates in the Afro-Barbadian population for a set of 40 AIMs, we have now typed 100 genome wide AIMs and additional chromosome 8 specific AIMs, allowing us to control for both genome wide and local admixture. All genotyping has been completed and data are being analyzed using logistic regression. Our data will be used to further validate the overall risk of prostate cancer with the 8q locus among men of recent African decent. We hope to continue our investigations to further refine the true causative allele contributing to prostate cancer risk at the 8q locus.