A prospective study of dietary acrylamide intake and pancreatic cancer risk Free

B49

Introduction: Acrylamide was first detected in various heat-treated carbohydrate-rich foods in 2002. Based on animal studies, it is classified as a probable human carcinogen. Occupational exposure to acrylamide was associated with an increased risk of pancreatic cancer. Whether dietary intake of acrylamide is associated with pancreatic cancer has not been studied before.
 >Objective: To prospectively examine the association between dietary acrylamide intake and pancreatic cancer risk (PC).
 >Methods: The Netherlands Cohort Study on diet and cancer started in 1986 and included 120,852 men and women, aged 55-69 years. Data were processed and analyzed using the case-cohort approach, in which person years were estimated from a subcohort (n = 5000). The acrylamide intake of subcohort members and cases was assessed with a food frequency questionnaire and was based on chemical analysis of all relevant Dutch foods. Acrylamide intake was analyzed in quintiles of intake and continuously (per 10 microgram/day).
 >Results: After 13.3 years of follow-up, there were 349 cases with complete dietary data, including 233 cases with microscopically confirmed pancreatic cancer. The average daily acrylamide intake of the subcohort was 21.8 μg, with a range of 1.0-125.3 μg.
 >In multivariate analysis and compared to participants with the lowest quintile of acrylamide intake, the HRs of all pancreatic cancers for quintile 2, 3, 4 and 5 were 1.02, 0.96, 0.87 and 0.98, respectively (95% confidence interval (CI) for quintile 5, 0.68-1.40; p for trend, 0.63). The risk of pancreatic cancer was 1.06 (95% CI, 0.96-1.17) per 10 microgram increase of daily acrylamide intake.
 >When the analysis was restricted to never or former smokers the HRs of all pancreatic cancers for quintile 2, 3, 4 and 5 compared to the lowest quintile were 0.88, 1.62, 1.09 and 1.02, respectively (95% CI for quintile 5, 0.51-2.02; p for trend, 0.79).
 >HRs did not change if the analysis was restricted to microscopically confirmed cases of pancreatic cancer.Conclusions: This study does not support for an association between dietary acrylamide intake and the risk of pancreatic cancer.