Adipocytokines and dysplastic aberrant crypt foci

A16

Background and aims: Dysplastic aberrant crypt foci (dACF) are possibly the earliest precursors of colorectal cancer (CRC). We found the correlation between dACF and visceral fat obesity, not subcutaneous fat obesity. Visceral fat has a productive function of adipocytokines, such as adiponectin, leptin, IGF-1, resistin and TNF-alpha. The aim of this study is to elucidate the relation between dACF and these adipocytokines. Methods: dACF were examined in 29 cases with magnifying colonoscopy in Yokohama City University Hospital, and distinguished non-dysplastic or dysplastic ACF endoscopically. All were personally interviewed to ascertain risk factors for CRC such as age, parameters of obesity, diabetes mellitus, adipocytokines. Results: Our results showed a clear inverse correlation between adiponectin and number of dACF, and had a correlation between visceral fat and number of dACF. Adiponectin is the only factor that has correlation with the number of dACF in these adipocytokines. Conclusions: These results suggest that visceral fat and low level of adiponectin play an important role in the formation of dACF. To increase adiponectin may be a prevention target of the early stage of colon carcinogenesis.