Anticarcinogenesis effect of a selective COX2 inhibitor: Celecoxib

B91

Although cyclooxygenase-2(Cox-2) is known as one of the critical factor in carcinomas of various organs, the importance of Cox-2 expression in oral squamous cell carcinoma has not been fully discovered yet. The purpose of this study is to evaluate the anti-cancer effect of selective cox-2 inhibitor, celecoxib in 6 oral squamous cell carcinoma cell lines with respect to cytotoxicity test, in vitro invasion,MMP-2 expression,tumorigenesis assay and anti-carcinogenesis assay in animal model
 Administration of celecoxib demonstrated the concentration dependent cytotoxicity and anti-invasive potential in 3 cell lines. There was no significant difference in the expression of MMP-2. In hamster model, celecoxib treated group showed delayed oral carcinogenesis but complete prevention was not observed. Celexocib showed no inhibitory effect on the tumorigenesis in nude mouse. In immunohistochemical study, the expression of VEGF was significantly reduced in hamster buccal pouch specimen.
 From these results, it can be postulated that cox-2 inhibition by celecoxib has the possibility of chemopreventive effect which may come from reducing the angiogenesis and this can be a clue for highlighting celecoxib as one of treatment options of oral squamous cell carcinoma.