Evaluation of clinical, scintigraphic and morphological diagnostic features of thyroid neoplasms.

B201

Aim : To see the clinical, scintigraphic presentation and frequency of neoplastic lesions of the thyroid in a descriptive cross sectional study. Materials and Methods: All thyroid samples submitted and reported at the Department of Pathology, King Edward Medical University, Lahore during a 5 year period commencing from 1^st July 1999 to 30th June 2004. Results: Out of 1623 solitary thyroid nodules, 427 (26.3%) were shown to comprise of neoplastic lesions and were more common in females as compared to males giving a male to female ratio of 1:3.5. Regarding neoplastic lesions 320 (75%) were benign adenoma and 107(25%) were malignant. In the malignant category papillary carcinoma was the commonest (71%), followed by Follicular carcinoma (12%). Other malignant lesions were rare like , Anaplastic carcinoma (6.5%), Medullary carcinoma (3.7%), Lymphoma (1.8%), poorly differentiated carcinoma (1.8%) and Hurthle cell carcinoma (0.9%). A few of the cases (1.8%) comprised of malignancies showing local extension into the thyroid. One case of MC was associated with MEN II and one case of FC was under 20 years and associated with distance metastasis. Conclusions: Neoplastic lesions were more common in middle age women. The prevalence of malignant tumors was high from 31-60 years and the peak age was 31-40 (20-30%), it is increasing in younger patients. Most of the patients of thyroid neoplasms presented as a painless cold solitary nodule on scan, while a few presented with MNG and cysts. Most of the cases have normal thyroid profile. Very few patients were iodine deficient.