Metabolic syndrome and precancerous lesions of colon cancer.

A39

Background and aims: Metabolic syndrome has been associated with an increased risk of colon cancer, and this is a major health concern because of its death rates remain unacceptably high. We evaluated to the association that of obesity, insulin resistance, hyperlipidemia, and other factors of metabolic syndrome with subsequent diagnosis of precancerous lesion of colon cancer. Aberrant crypt foci (ACF) identified in the colonic mucosa to colorectal carcinogens has also been recognized in human colons. Methods: ACF was examined in 41 cases with magnifying colonoscopy in Yokohama City University Hospital. All were personally interviewed to ascertain risk factors for colorectal cancer. We evaluated the association between age, body mass index (BMI), waist, diabetes mellitus, serum lipid, visceral fat, subcutaneous fat and ACF. Results: Waist, BMI, Inslin and visceral fat were significantly associated with ACF in univariate analysis. Visceral fat was associated with ACF in multiple regression analysis. Conclusions: These results suggest that visceral fat obesity and hyperinsulinemia are important targets for colon cancer prevention. Additional larger studies of these factors may clarify colon cancer carcinogenesis.