Background: Stroke is the fifth-leading cause of death in the US. Previous studies have found that the prevalence of precancerous lesions in patients with ischemic stroke is higher than that in the general population. Studies show that Asian-Americans are more likely to experience a severe ischemic stroke in comparison with other racial groups. Although predisposing risk factors for stroke and stroke epidemiology have been studied extensively, racial-ethnic disparities in stroke incidence and prevalence are well documented but less understood. Methods: This study uses a sample of 18889 adults who self-reported suffering stroke in the Behavioral Risk Factor Surveillance System (BRFSS-2018), which includes five racial and ethnic groups (White, Black, American Indian, Hispanic, and Asian American populations). Factors associated with stroke are used in data analysis. Results: Compared with other racial groups (White/Black/American Indian/Hispanic) in the United States, Asians are at an elevated risk of suffering a stroke. Asians reported a significantly higher rate of stroke in younger age group: in groups aged 18-34, Asians reported the highest rate of having stroke (15.4% vs. White, 1.9%; Black, 2.7%; American Indian, 4.7%; and Hispanic, 10.5%; p<0.001). In addition, among respondents with normal/under-weight, doing exercise, and no smoking, Asians also reported significant higher stroke rates. Specifically, among people being normal- or under-weight; 50.2% of Asians reported having stroke in comparing with White, 29.7%; American Indian, 29.5%; Hispanic, 26.3% and Black, 25.4% (p<0.001). Among people reported doing exercise, Asians (67.0%) reported the highest rate of stroke followed by Hispanic (59.5%), White (58.6%), Black (55.2%) and American Indian (53.3%) (p<0.001). Similarly, among people reported no smoking, Asians (75.6%) also reported a significant higher rate of stroke in comparing with White (66.6%), Hispanic (60.5%), Black (55.7%), and American Indian (44.8%) (p<0.001). More logistic regression results will be reported at presentation. Conclusion: Stroke incidence and prevalence are not uniform. Asian-Americans face unique disparities compared to their racial counterparts’ risk factors for stroke. Elucidating these underlying risk factors and identifying intervention strategies to address the stroke disparities experienced by Asian-Americans will improve both stroke and cancer prevention.

Citation Format: Helen Y. Xia, Wenyue Lu. Unique stroke disparity and cancer risk in Asian Americans [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-171.