Correction: A Computational Method to Classify Variants of Uncertain Significance Using Functional Assay Data With Application to BRCA1

^aThe posterior odds are equivalent to the Bayes Factor, Pr(Data|Damaging)/Pr(Data|Benign), because the prior distribution is uniform, and could be combined in this form with other conditionally independent data types.

^bKnown pathogenic variant (“negative control”).

^cWild–type, known benign variant (“positive control”).

^dVariant of unknown significance (VUS) previously classified as neutral with an estimated posterior probability of pathogenicity less than 0.0001, but blinded for purposes of model evaluation.

^eVUS previously classified as pathogenic with an estimated posterior probability greater than 0.999, but blinded for purposes of model evaluation.

^fVUS previously classified as pathogenic with an estimated posterior probability of between 0.99 and 0.999, but blinded for purposes of model evaluation.