Background:

There has been limited prior research on the association between infertility and risk of colorectal cancer.

Methods:

Data from postmenopausal women in the Women’s Health Initiative were used to estimate the association between self-reported infertility (12 months of trying to get pregnant without achieving a pregnancy) and the risk of colorectal cancer using Cox proportional hazard models.

Results:

No association was observed between infertility and risk of postmenopausal colorectal cancer [RR, 0.97; 95% confidence interval (CI), 0.87–1.08], invasive colorectal cancer (RR, 0.99; 95% CI, 0.88–1.10), or colorectal cancer mortality (RR, 0.89; 95% CI, 0.71–1.12).

Conclusions:

Infertility was not found to be associated with colorectal cancer risk among postmenopausal women. Risk did not vary by specific infertility diagnoses.

Impact:

Infertility may not be associated with colorectal cancer risk.

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