Yaghjyan and colleagues investigated the associations between reproductive factors and the variation (V) measure (a novel, objective, single summary measure of breast image intensity) among 3,814 cancer-free women. The V measure is positively associated with breast cancer independent of percent mammographic density. Among postmenopausal women, parity was inversely associated, and age at first birth and breastfeeding were positively associated with V. The authors show, for the first time, that the V measure may capture additional imaging information beyond percent mammographic density. This information may help to better elucidate the impact of specific risk factors on breast tissue architecture and ultimately breast cancer risk.

Previous studies have demonstrated that incorporating a polygenic risk score (PRS) to existing risk prediction models for breast cancer improves model fit, but to determine its clinical utility the impact on risk categorization needs to be established. Collister and colleagues compute the 10-year risk scores from two...

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