The risk for colorectal cancer and colon polyps, the precursors to colorectal cancer, varies between people for largely unclear reasons, one of which is field cancerization. The evidence for field cancerization in the colon has been modest to date. In this study, Yu and colleagues carried out studies using methylated EVL as a marker for field cancerization in the colon and a possible risk biomarker for colon polyps. The authors found mEVL associated with a 3X increased risk for colon polyps. Results provide more support for colon field cancerization and suggest mEVL may be a novel risk marker for colorectal cancer and therapeutic target for colorectal cancer chemoprevention.

Human papillomavirus (HPV) cell entry through host cell surface receptors could correlate with infectivity and may play a role in cervical precancer progression. It has been shown that heparan sulfate proteoglycans (HSPG), specifically the syndecan and glypican gene families are...

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