Colorectal cancer (CRC) screening has proven to be very effective in preventing this deadly disease. However, effectiveness can be improved, and costs can be reduced by using additional biomarkers for candidate selection. Arnau-Collell and colleagues developed a polygenic risk score and evaluated its effectiveness in determining which individuals should undergo a colonoscopy after a positive FIT result considering their CRC-associated genetic risk. The study highlights the potential application of these variants when applied to stratify people at a higher risk of CRC in the context of screening programs, while underlining the need to incorporate additional biomarkers.

Breast cancer incidence is greater among non-Hispanic White and Black women compared to other women. In a large population-based study, Barnard and colleagues observed that the distributions of two breast cancer risk factors, body mass index (BMI) and mammographic density (MD) varied dramatically by race and ethnicity, with the highest MD among Asian women...

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