Emerging data indicates genetic polymorphisms may affect the efficacy of aspirin for chemoprevention of colorectal cancer and may be used as a tool to improve risk assessment and identify individuals that are likely to benefit. Biltaji and colleagues created a decision analytical model to assess the potential benefit of a genotype-guided aspirin strategy for colorectal cancer chemoprevention in an average risk population. The authors concluded the approach was cost-effective and improved clinical outcomes. This model establishes a framework and the potential clinical utility for a precision medicine approach to targeted chemoprevention of colorectal cancer.

Examining excess mortality among cancer survivors relative to the general population can inform planning for surveillance and follow-up after cancer treatment. Anderson and colleagues examined patterns of excess mortality among women with endometrial cancer identified in the Surveillance, Epidemiology and End Results (SEER) database. Overall, endometrial cancer survivors had little excess mortality compared to the general...

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