Breast cancer is the most commonly diagnosed invasive cancer among women both globally and within the United States and the number one cause of cancer-related deaths among women globally (1, 2). Less than 1% of diagnosed breast cancers occur in men (2) and, therefore, male breast cancer is not included in this report. Breast cancer is an etiologically and clinically heterogeneous disease. Many risk factors, primarily hormone related, have been identified and these associations can vary by breast cancer subtype. Survival has increased over the past few decades, with the introduction of screening mammography and improved treatments. However, progress has not been seen equally among all ethnicities/races or with all breast cancer subtypes (e.g., triple negative).

Breast cancer accounts for 25% of new cancer cases in women globally, with an estimated 2,088,849 female breast cancers occurring worldwide in 2018 (46.3/100,000 women; refs. 1, 3). On...

You do not currently have access to this content.