Effectiveness of fecal immunochemical test (FIT) for colorectal cancer screening may be compromised when patients do not adhere to a regular schedule, while having no standard measure of repeat FIT presents challenges for assessing effectiveness across patient populations and health systems. To address these challenges, Murphy and colleagues compared three measures of repeat FIT in a large population of screen-eligible patients. Estimates of repeat FIT varied widely by the measure used. For example, using a prior screeners measure, 16% of patients completed repeat FIT, whereas 53% of patients completed repeat FIT using proportion of time covered measures. An important next step is to examine the association of these measures with clinical outcomes, such as stage of diagnosis and mortality.

Semmes and colleagues developed a novel methodology for incorporating phenome-wide association study (PheWAS) data into genetic association studies. They applied their methodology to childhood leukemia, identifying novel pleiotropic loci contributing to...

You do not currently have access to this content.