Multiple features of the tumor microenvironment, including the orientation of collagen fibers, may influence breast cancer progression by facilitating cancer cell migration. In this cohort study of women diagnosed with ductal carcinoma in situ (DCIS) during 1995–2006 and followed an average of 15 years, Conklin and colleagues characterized DCIS lesions according to syndecan-1 expression and collagen fiber alignment using novel microscopy techniques. Although collagen alignment and stromal syndecan-1 expression did not predict recurrence, collagen fibers perpendicular to the duct perimeter were more frequently observed in DCIS lesions with features typical of poor prognosis.

Physical activity may be linked to better cancer survival, but the type of exercise and the conditions that optimize this benefit are poorly understood. Winters-Stone and colleagues pooled data from three yearlong clinical trials in breast cancer survivors to determine whether resistance exercise, prescribed for musculoskeletal health, could also reduce inflammatory markers and growth factors linked to...

You do not currently have access to this content.