High-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma—Letter

Garland, Suzanne M.; Tabrizi, Sepehr N.; Segelov, Eva; Dwyer, Dominic E.; Crowe, Philip J.

doi:10.1158/1055-9965.EPI-10-0920

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Letters to the Editor| February 06 2011

High-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma—Letter

Suzanne M. Garland;

Suzanne M. Garland

Authors' Affiliations: 1Department of Microbiology and Infectious Diseases and Regional WHO HPV Reference Laboratory, Royal Women's Hospital, Parkville, Victoria; 2Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria; 3St Vincents Clinical School, University of New South Wales, Sydney; 4Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital and University of Sydney, Westmead; and 5UNSW POW Hospital, High Street, Randwick, New South Wales, Australia

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Sepehr N. Tabrizi;

Sepehr N. Tabrizi

Authors' Affiliations: 1Department of Microbiology and Infectious Diseases and Regional WHO HPV Reference Laboratory, Royal Women's Hospital, Parkville, Victoria; 2Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria; 3St Vincents Clinical School, University of New South Wales, Sydney; 4Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital and University of Sydney, Westmead; and 5UNSW POW Hospital, High Street, Randwick, New South Wales, Australia

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Eva Segelov;

Eva Segelov

Authors' Affiliations: 1Department of Microbiology and Infectious Diseases and Regional WHO HPV Reference Laboratory, Royal Women's Hospital, Parkville, Victoria; 2Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria; 3St Vincents Clinical School, University of New South Wales, Sydney; 4Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital and University of Sydney, Westmead; and 5UNSW POW Hospital, High Street, Randwick, New South Wales, Australia

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Dominic E. Dwyer;

Dominic E. Dwyer

Authors' Affiliations: 1Department of Microbiology and Infectious Diseases and Regional WHO HPV Reference Laboratory, Royal Women's Hospital, Parkville, Victoria; 2Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria; 3St Vincents Clinical School, University of New South Wales, Sydney; 4Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital and University of Sydney, Westmead; and 5UNSW POW Hospital, High Street, Randwick, New South Wales, Australia

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Philip J. Crowe

Authors' Affiliations: 1Department of Microbiology and Infectious Diseases and Regional WHO HPV Reference Laboratory, Royal Women's Hospital, Parkville, Victoria; 2Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria; 3St Vincents Clinical School, University of New South Wales, Sydney; 4Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital and University of Sydney, Westmead; and 5UNSW POW Hospital, High Street, Randwick, New South Wales, Australia

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Author & Article Information

Received: August 29 2010

Revision Received: September 21 2010

Accepted: October 24 2010

Online ISSN: 1538-7755

Print ISSN: 1055-9965

2011

Cancer Epidemiol Biomarkers Prev (2011) 20 (2): 408.

https://doi.org/10.1158/1055-9965.EPI-10-0920

See the Reponse, p. 409

We read with interest the recent article excluding human papillomavirus (HPV) as a significant contributor in esophageal squamous cell cancers (ESCC), at least in Australia (1). This is in contradistinction to oropharyngeal cancers (OPC) where there is compelling epidemiologic and molecular evidence indicating HPV as the etiology of a subset of cases. Within Australia, there is a changing epidemiology of OPCs. In a recent study of 302 cases, the incidence of HPV-related OPCs increased from 19% in 1987 to 1990, 47% in 2001 to 2005, to 60% in 2005 to 2006 (2). Reports worldwide vary considerably in finding HPV in ESCC: with rates up to 81% (3). The clinical implications of excluding HPV as a major contributor to ESCC are important, particularly as HPV-related cancers have better prognosis and chemoradiation responses than their non-HPV counterparts.

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High-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma—Letter