AURKA and Breast Cancer in BRCA1/2 Mutation Carriers Available to Purchase

To the Editors: A recent article reported, “the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer found in 3,884 breast cancer BRCA1 and BRCA2 carrier cases compared to unaffected BRCA1/2 mutation carriers” (1). This agrees with our previously published results where no association of increased breast cancer risk was found in 107 BRCA1 and BRCA2 breast cancer carrier cases compared with 653 unaffected wild-type BRCA1/2 controls (2), which Couch et al. did not cite. We also found strong association with homozygous 31I in 652 sporadic breast cancer cases compared with unaffected controls. In addition, we compared the F31I polymorphism in the 107 BRCA1/2-mutated breast cancer cases with 40 unaffected BRCA2 mutation carriers. We found that the unaffected BRCA2 mutation carriers had clearly higher 31I allele frequency of 27.5% compared with 21.0% in BRCA1/2 breast cancer cases, which indicates that...