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News
Publisher: American Association for Cancer Research
Published: 04 February 2025
Abstract
A study of more than 460,000 women shows that AI assistance can help radiologists spot nearly 18% more breast tumors on mammograms. The study also found that AI does not increase the recall rate for further screening, and that it can reduce the amount of time it takes radiologists to read mammograms.
News
Publisher: American Association for Cancer Research
Published: 03 February 2025
Abstract
The FDA’s Center for Drug Evaluation and Research issued its annual report on the approval of drugs, which announced that the agency OK’d 50 novel drugs in 2024, 15 of which were related to cancer care and treatment.
News
Publisher: American Association for Cancer Research
Published: 30 January 2025
Abstract
An investigational blood test accurately detected colorectal cancer in a study involving more than 27,000 participants. If widely implemented, the test could increase screening adherence among those hesitant to receive a colonoscopy.
News
Publisher: American Association for Cancer Research
Published: 25 January 2025
Abstract
Aspirin reduced the risk of colorectal cancer recurrence by more than 50% in patients with PI3K -mutated disease who took a low dose once a day for 3 years, according to newly released data from the ALASCCA study. The findings may have a significant effect on the treatment of this form of disease, which accounts for about 30% of all colorectal cancers.
News
Publisher: American Association for Cancer Research
Published: 24 January 2025
Abstract
Seeking to understand why the lungs are a favored organ of metastasis, researchers have uncovered a signaling role for the classical metabolite aspartate. In lung-disseminated breast cancer cells, aspartate induces NMDA receptor activity, subsequent eIF5A hypusination, and translational reprogramming that promotes collagen synthesis and aggressive lung metastases.
News
Publisher: American Association for Cancer Research
Published: 22 January 2025
Abstract
Two CRISPR-based studies systematically evaluated more than 6,000 BRCA2 mutations, reclassifying most ambiguous variants as either cancer-promoting or benign. The combination of genome-editing and functional assays provides a practical framework for improving genetic testing and risk assessment in hereditary cancer care.
News
Publisher: American Association for Cancer Research
Published: 21 January 2025
Abstract
The Palisades and Eaton Fires affecting the Los Angeles, CA area have not significantly impacted cancer care or research, but patients, faculty, and staff of cancer centers have lost homes. Nevertheless, caregivers have shown a selfless dedication to patients.
News
Publisher: American Association for Cancer Research
Published: 15 January 2025
Abstract
Large germline structural variants are a risk factor for some pediatric cancers. These variants are distributed throughout the genome and, surprisingly, are heavily enriched in male patients.
News
Publisher: American Association for Cancer Research
Published: 14 January 2025
Abstract
Highlighting the need for regional collaboration in South Asia, a group of leading oncology scholars is calling for targeted investments and policy reforms to address inequities in cancer prevention, diagnosis, treatment, and research, particularly among vulnerable populations like the Rohingya refugees. Key recommendations include strengthening healthcare infrastructure, expanding workforce training, and fostering culturally sensitive outreach and collaborative research networks to improve cancer-related outcomes across the region.
News
Publisher: American Association for Cancer Research
Published: 09 January 2025
Abstract
The FDA’s accelerated approval pathway allows for quicker access to drugs based on surrogate endpoints, such as progression-free survival. However, when considering new cancer drugs, patients are not always willing to forgo evidence of an overall survival benefit in favor of quicker access, according to a recent study.
News
Publisher: American Association for Cancer Research
Published: 31 December 2024
Abstract
Basic and translational research shows that a low-carbohydrate, high-fat ketogenic diet, which is rich in the metabolite β-hydroxybutyrate, can increase the proliferation of chimeric antigen receptor T-cell therapies and better suppress tumor growth. Scientists have launched a phase I study to test their findings in patients.
News
Publisher: American Association for Cancer Research
Published: 30 December 2024
Abstract
In a phase II trial, the ROR1-targeting antibody–drug conjugate zilovertamab vedotin led to a complete response in nearly 100% of patients with diffuse large B-cell lymphoma.
News
Publisher: American Association for Cancer Research
Published: 19 December 2024
Abstract
The cereblon E3 ligase modulator cemsidomide showed activity against multiple myeloma and two types of non–Hodgkin lymphoma in a phase I study.
News
Publisher: American Association for Cancer Research
Published: 17 December 2024
Abstract
Machine learning could better stratify patients with metastatic ER-positive, HER2-negative breast cancer who are more or less likely to benefit from CDK4/6 inhibition up front. At Memorial Sloan Kettering Cancer Center, two models trained on clinical and genomic factors, respectively, were effective in predicting disease progression risk; combining these factors produced a third model that outperformed the others in terms of analytical power.
News
Publisher: American Association for Cancer Research
Published: 17 December 2024
Abstract
The Biden Cancer Moonshot initiative announced its second cohort of Cancer Moonshot Scholars, awarding $6 million to 11 early-career researchers and research teams from underrepresented communities to advance innovative cancer research. The program aims to foster diverse perspectives and accelerate progress in cancer research.
News
Publisher: American Association for Cancer Research
Published: 17 December 2024
Abstract
Patients with low-risk ductal carcinoma in situ who received active monitoring had similar rates of invasive cancer as well as quality of life, anxiety, and depression, compared with those who underwent surgery, suggesting that active monitoring alone may be appropriate for some patients.
News
Publisher: American Association for Cancer Research
Published: 16 December 2024
Abstract
Interest is growing in the potential of genetically reprogramming B cells to pump out protein-based drugs in patients’ own bodies. An initial report from one company, Be Biopharma, at the American Society of Hematology Annual Meeting and Exposition, provides proof-of-concept, showing that B cells engineered to secrete a bispecific T-cell engager are active in mice with ALL.
News
Publisher: American Association for Cancer Research
Published: 13 December 2024
Abstract
A common germline variant of PCSK9 significantly increases the risk of breast cancer metastasis, a new study has revealed. The finding—a first example of inherited genes driving metastatic progression in breast cancer—also highlights a new therapeutic opportunity, suggesting that PCSK9 inhibitors, originally developed for cholesterol lowering, could be repurposed to prevent the spread of high-risk breast tumors.
News
Publisher: American Association for Cancer Research
Published: 12 December 2024
Abstract
Combining the investigational selective estrogen receptor degrader imlunestrant with the CDK4/6 inhibitor abemaciclib improved progression-free survival compared with standard care in patients with ER-positive, HER2-negative breast cancer who had already tried endocrine therapy. The effect was seen regardless of whether the cancers harbored ESR1 mutations.
News
Publisher: American Association for Cancer Research
Published: 11 December 2024
Abstract
Research suggests that digital twins of patients can provide more effective treatment recommendations than standard of care. The analysis suggested that the treatments recommended by the virtual doubles would lead to improved drug responses and increased survival. The twins could also recapitulate the results of clinical trials.
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