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News
Publisher: American Association for Cancer Research
Published: 07 February 2025
Abstract
Major Finding: An analysis of immune responses in children with cancer reveals the effects of age and tumor type. Concept: Pediatric tumors have varied mutational burden which correlates with immune cell infiltration. Impact: Understanding systemic immune responses in children may guide development of targeted immunotherapies.
News
Publisher: American Association for Cancer Research
Published: 05 February 2025
Abstract
Major Finding: Cancer cells transfer mitophagy-resistant mitochondria to tumor-infiltrating lymphocytes (TIL) that impair antitumor activity. Concept: Deubiquitinase USP30 protects cancer cell-derived mitochondria from ROS-induced mitophagy in TILs. Impact: Inhibiting mitochondrial transfer may improve responses to immune checkpoint inhibitors in certain cancers.
News
Publisher: American Association for Cancer Research
Published: 04 February 2025
Abstract
Main Finding: High-grade osteosarcomas frequently exhibit a loss–translocation–amplification (LTA) pattern of chromothripsis that inactivates TP53 and amplifies oncogenes. Concept: Ongoing chromothripsis in osteosarcoma contributes to rapid subclonal evolution and heterogeneity. Impact: This study proposes a prominent mechanism of chromothripsis that furthers the understanding of osteosarcoma tumor evolution.
News
Publisher: American Association for Cancer Research
Published: 30 January 2025
Abstract
Main Finding: HER2 + breast tumors and high-risk ER + breast tumors share genomic features that reflect similar mechanisms of tumor evolution. Concept: The genomic architecture of breast cancer is constrained by three primary archetypes, in which HER + and high-risk ER + group together. Impact: This study suggests that these two subgroups, conventionally treated distinctly, may share therapeutic vulnerabilities.
News
Publisher: American Association for Cancer Research
Published: 28 January 2025
Abstract
Main Finding: A phase I trial supported the safety and feasibility of repeated intracranial infusions of B7-H3 CAR T cells for DIPG. Concept: B7-H3 is an immunoregulatory protein expressed on the surface of DIPG tumor cells. Impact: These results from the BrainChild-03 trial warrant further investigation of B7-H3 CAR T-cell therapy for DIPG.
News
Publisher: American Association for Cancer Research
Published: 27 January 2025
Abstract
Major Finding: IL-33 drives the formation of tertiary lymphoid structures in inflammation and pancreatic cancer. Concept: IL-33 activates gut-derived group 2 innate lymphoid cells to induce tertiary lymphoneogenesis. Impact: Recombinant IL-33 protein induces tertiary lymphoid structures and demonstrates antitumor activity.
News
Publisher: American Association for Cancer Research
Published: 24 January 2025
Abstract
Main Finding: Early stages of glioblastoma progression resemble an injury response program observed in the brain. Approach: Temporal analysis of malignant and nonmalignant cell states during gliomagenesis reveal an injury-like niche and evolutionary hierarchy. Impact: This study provides a foundation that may inform the management and treatment of early-stage glioblastoma.
News
Publisher: American Association for Cancer Research
Published: 22 January 2025
Abstract
Main Finding: AI-based models may enhance the clinical detection of ovarian cancer by supporting ultrasound analysis. Concept: Transformer-based models trained on data from retrospective multicenter cohorts can outperform human examiners and streamline clinical triage. Impact: This study demonstrates the potential clinical utility of using AI to improve the accuracy of ovarian cancer diagnosis.
News
Publisher: American Association for Cancer Research
Published: 16 January 2025
Abstract
Major Finding: Elevated bile acids (BA) in liver cancer contribute to T-cell dysfunction. Concept: BA accumulation in T cells promotes ER stress, reducing effector function and viability. Impact: Modulating BA synthesis or intake may improve immunotherapy response in liver cancer.
News
Publisher: American Association for Cancer Research
Published: 13 January 2025
Abstract
Major Finding: Generation of the zinc-bound proteome enables identification of new targetable vulnerabilities in cancer.
Concept: Zinc binding inhibits glutathione reductase activity, leading to oxidative stress and cytotoxicity.
Impact: Dietary zinc supplementation may help improve outcomes in lung cancers reliant on glutathione reductase
News
Publisher: American Association for Cancer Research
Published: 10 January 2025
Abstract
Main Findings: Engineering oncogene-containing extrachromosomal DNA generates preclinical immunocompetent mouse models of cancer. Concept: Cre-mediated recombination of a region flanked by loxP sites of the same orientation enable circularization and subsequent amplification under selection. Impact: This study advances preclinical modeling of human cancer that will inform the understanding of focal amplification–driven tumorigenesis.
News
Publisher: American Association for Cancer Research
Published: 09 January 2025
Abstract
Major Finding: Fasting-mimicking diet plus chemotherapy exhibits high response rates in triple-negative breast cancer. Concept: Tumors of complete responders exhibit an early downregulation of glucose metabolism genes and pathways. Impact: Early downregulation of glycolysis may be a predictive biomarker of response to fasting-mimicking diets.
News
Publisher: American Association for Cancer Research
Published: 08 January 2025
Abstract
Main Findings: Assessing selection for biallelic loss of tumor suppressor genes (TSG) reveals TSG zygosity as an important feature of cancer etiology. Approach: An allele-specific analysis of somatic TSG alterations was performed on tumors of 67 cancer types from over 48,000 patients. Impact: This study sheds light on mechanisms of TSG inactivation and proposes TSG zygosity as a predictive biomarker of response.
News
Publisher: American Association for Cancer Research
Published: 07 January 2025
Abstract
Main Findings: Complete blood count indices are patient-specific and stable over decades in healthy adults. Concept: These hematologic setpoints are deep physiological phenotypes associated with variation in clinical risk. Impact: A deeper understanding of patient-specific setpoints may inform the management of many common conditions, including myeloproliferative neoplasms.
News
Publisher: American Association for Cancer Research
Published: 06 January 2025
Abstract
Main Findings: Visugromab, a GDF-15 blocking antibody, is tolerable and elicits clinical responses in combination with nivolumab. Concept: GDF-15 may represent a mechanism of anti-PD-1 resistance that can be targeted to enhance antitumor immunity. Impact: This phase I/IIa trial supports the safety and further clinical evaluation of this combination, particularly in NSCLC and urothelial cancer.
News
Publisher: American Association for Cancer Research
Published: 27 December 2024
Abstract
Major Finding: Tumor-connected neurons promote glioblastoma growth, invasion, and resistance to radiotherapy. Concept: Rabies virus–based retrograde tracing of neurons reveals their integration with glioblastoma cells. Impact: Disrupting neuron–tumor networks may enhance the efficacy of radiotherapy in glioblastoma.
News
Publisher: American Association for Cancer Research
Published: 26 December 2024
Abstract
Major Finding: Incorporating a modified CD3ε intracellular domain into a chimeric antigen receptor (E-CAR) improves signaling.
Concept: E-CARs phase separate and form mature synapses that support sustained antitumor killing.
Impact: This study informs the development of CAR T-cell therapies with enhanced antigen sensitivity and persistence.
News
Publisher: American Association for Cancer Research
Published: 23 December 2024
Abstract
Major Finding: The CD8 + T cell epigenome is regulated by metabolic changes in acetyl-CoA production. Concept: Exhausted T (TEX) cells shift to citrate-dependent acetyl-CoA utilization for histone modification. Impact: This study informs the development of metabolic- and epigenetic-based approaches to modulate T-cell function.
News
Publisher: American Association for Cancer Research
Published: 20 December 2024
Abstract
Major Finding: Glucocorticoids modulate glioblastoma growth and synchronize circadian gene expression with the host. Concept: Effects of glucocorticoids are dependent on glucocorticoid receptor signaling and the circadian clock. Impact: Targeting glucocorticoid receptor signaling may be a promising therapeutic strategy for glioblastoma.
News
Publisher: American Association for Cancer Research
Published: 19 December 2024
Abstract
Major Finding: Pharmacologic inhibition of EZH2 sensitizes preclinical models of B cell lymphoma to T-cell immunotherapy. Concept: EZH2 inhibition enhances T-cell recruitment, T-cell–B-cell interactions, and a T-cell memory phenotype. Impact: These preclinical findings have prompted the initiation of two clinical trials in B cell lymphoma.
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