Ferroptosis Is Induced by Lysosomal Iron Activation in Cancer Cells Available to Purchase

Major Finding: Iron activation within the lysosome triggers oxidative membrane lipid degradation and ferroptosis.
Concept: Fentomycin-1 induces phospholipid oxidation and ferroptosis in cancer cells by activating lysosomal iron.
Impact: Lysosomal iron is a druggable target in primary cancers, metastases, and drug-tolerant persister cells.