A Single-Cell Atlas Reveals Characteristics of Pan-Cancer Brain Metastases Available to Purchase

Major Finding: Brain metastases that arise from various primary sites characteristically harbor chromosomal instability and an immunosuppressive stromal/immune composition.
Approach: A comprehensive single-cell transcriptomic atlas of pan-cancer human brain metastases was constructed.
Impact: These shared characteristics and dependencies of brain metastases may be targeted therapeutically.