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ROS Sensing Regulates Mitochondrial Translation and Chemotherapy Response Available to Purchase
April 18, 2025
Major Finding: ROS levels regulate retromer activity, influencing mitochondrial translation and chemotherapy response.
Concept: VPS35 cysteine oxidation decreases SLC7A1-mediated arginine import and mitochondrial tRNA charging.
Impact: VPS35 levels and oxidation state may reflect tumor sensitivity to ROS-modulating chemotherapies.
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