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Dietary Fat Promotes Triple-Negative Breast Cancer through FABP5–mTOR Available to Purchase

April 18, 2025
Major Finding: Dietary ω-6 linoleic acid (LA) promotes oncogenic mTOR signaling in triple-negative breast cancer (TNBC).
Concept: TNBCs express the fatty acid binding protein FABP5, which senses ω-6 LA and promotes mTOR-Raptor complex function.
Impact: This study highlights FABP5 as a functional link between dietary fat and TNBC that warrants further investigation.
DOI:https://doi.org/10.1158/2159-8290.CD-RW2025-039
Publisher:American Association for Cancer Research
Article Type:
Research Watch
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