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Ligand Engagement Induces LAG3 Checkpoint Activity through Ubiquitination
April 9, 2025
Major Finding: Ligand engagement–induced polyubiquitination activates LAG3 by blocking LAG3 membrane binding.
Concept: LAG3 ubiquitination is mediated by Cbl family ligases and is required for LAG3 checkpoint function.
Impact: Coexpression of LAG3 and CBL is a potential biomarker for response to LAG3-targeted immunotherapy.
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