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Loss–Translocation–Amplification Chromothripsis Drives Osteosarcoma Evolution

February 4, 2025
Main Finding: High-grade osteosarcomas frequently exhibit a loss–translocation–amplification (LTA) pattern of chromothripsis that inactivates TP53 and amplifies oncogenes.
Concept: Ongoing chromothripsis in osteosarcoma contributes to rapid subclonal evolution and heterogeneity.
Impact: This study proposes a prominent mechanism of chromothripsis that furthers the understanding of osteosarcoma tumor evolution.
DOI:https://doi.org/10.1158/2159-8290.CD-RW2025-013
Publisher:American Association for Cancer Research
Article Type:
Research Watch
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