Tumor Suppressor Gene Zygosity Can Predict Therapeutic Response in Cancer

Main Findings: Assessing selection for biallelic loss of tumor suppressor genes (TSG) reveals TSG zygosity as an important feature of cancer etiology.
Approach: An allele-specific analysis of somatic TSG alterations was performed on tumors of 67 cancer types from over 48,000 patients.
Impact: This study sheds light on mechanisms of TSG inactivation and proposes TSG zygosity as a predictive biomarker of response.