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Characterization of Extrachromosomal DNA During Cancer Progression
November 25, 2024
Major Finding: Extrachromosomal DNA (ecDNA) confers fitness advantages during tumor progression and metastasis.
Approach: ecDNA was assessed across multiple cohorts compiled across disease stage, treatment status, and time.
Impact: This study suggests targeting processes that contribute to ecDNA formation and maintenance as a therapeutic strategy.
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