T Cells Home to Intracranial Metastases Via ICAM-1⁺ Peritumoral Venous Vessels

Major Finding: Antitumor T cells are recruited to intracranial metastases through ICAM-1⁺ peritumoral venous vessels (PVV).
Concept: PVVs mediate T-cell recruitment and motility, which can be enhanced by immune checkpoint blockade.
Impact: This study reveals PVVs as a primary site of T-cell extravasation and informs immunotherapeutic development.