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Alveolar Macrophages Control Cancer Cell Dormancy in Breast Metastases
October 28, 2024
Major Finding: Alveolar macrophages (AM) induce dormancy in early disseminated cancer cells (DCC) in the lung.
Concept: TGF-β2-TGF-βRIII signaling mediates DCC dormancy and is subverted during resistance in later stages.
Impact: This study highlights a heterotypic cell–cell interaction that may be leveraged for therapeutic benefit.
DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-128
Publisher:American Association for Cancer Research
Article Type:
Research Watch
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