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Linking Transcriptional Kinases to BCL6 Induces Cancer Cell Death
October 23, 2024
Main Finding: A bivalent molecule that links CDK9 and BCL6 enables CDK9-dependent reactivation of apoptotic genes.
Concept: CDK-TCIP1 brings CDK9 to BCL6 target genes, where CDK9 phosphorylates Pol II and promotes transcription.
Impact: This study demonstrates that kinase activity can be redirected to elicit cancer cell–specific killing.
DOI:https://doi.org/10.1158/2159-8290.CD-RW2024-126
Publisher:American Association for Cancer Research
Article Type:
Research Watch
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