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Pan-KRAS Degraders Effectively Target KRAS-Mutant Cancers
October 2, 2024
Major Finding: A small molecule degrader targets 13 of the most common oncogenic KRAS alleles in vitro and in vivo.
Concept: ACBI3 is a proteolysis-targeting chimera that engages multiple oncogenic KRAS alleles with high affinity.
Impact: This study provides preclinical proof of concept for the antitumor efficacy of pan-KRAS degradation.
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