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Coagulation Factor X Directly Fuels the Growth of Prostate Cancer
September 30, 2024
Major Finding: Coagulation factor X (FX) promotes proliferation and androgen independence in prostate cancer.
Concept: Immunosuppressive neutrophils secrete FX, which binds PAR2 on PCa cells and promotes ERK signaling.
Impact: Targeting FX in combination with enzalutamide may benefit patients with castration-resistant PCa.
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