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The Aged Male TME Promotes Melanoma Invasion and Therapeutic Resistance
September 27, 2024
Major Finding: Age-associated changes in male fibroblasts induce a phenotypic switch to invasive and resistant melanoma.
Concept: Aged male dermal fibroblasts secrete BMP2, regulating tumor progression and therapeutic resistance.
Impact: This study highlights an aging-driven mechanism that may underpin sex-associated melanoma outcomes.
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