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A Gasdermin D Agonist Triggers Pyroptosis and Antitumor Immunity
September 23, 2024
Major Finding: Agonism of gasdermin D (GSDMD) triggers pyroptosis in cancer cells and inhibits tumor growth.
Concept: The efficacy of the GSDMD agonist, DMB, is dependent on tumor cell GSDMD expression and the immune response.
Impact: The synergy and absence of toxicity with immunotherapy position DMB as a promising anticancer therapeutic.
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