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Reactive Oxygen Species Drive Micronuclear Collapse in Cancer Cells
September 20, 2024
Major Finding: Reactive oxygen species from mitochondria–micronuclei interactions drive micronuclear collapse.
Concept: Localization of p62 and CHMP7 to micronuclei disrupts ESCRT activity, leading to micronuclear rupture and interfering with micronuclear envelope repair.
Impact: This highlights a potentially targetable mechanism by which oxidative stress promotes chromosomal instability.
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