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The Dynamics of Ductal Tree Remodeling Shape Mammary Field Cancerization
September 18, 2024
Major Finding: Mechanisms of clonal expansion during the estrous cycle can promote mammary field cancerization.
Concept: Ductal network remodeling eliminates the majority of mutant clones but supports mutant clonal expansion.
Impact: This study sheds light on how breast tissue homeostasis may influence breast cancer initiation.
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