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An Age-Associated Increase in Myelopoiesis Promotes Lung Cancer Development
September 16, 2024
Major Finding: Hematopoietic aging enhances the growth of non−small cell lung cancer by deregulating myelopoiesis.
Concept: An age-associated decrease in Dnmt3a upregulates Il1a and elevates an immunosuppressive myeloid response.
Impact: Blocking IL-1α-dependent myelopoiesis may be a promising therapeutic strategy for various cancers.
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